Áàçà çíàíèé ñòóäåíòà. Ðåôåðàò, êóðñîâàÿ, êîíòðîëüíàÿ, äèïëîì íà çàêàç

ÝÏÎ-?

.

                        2ÈÍÒÅÐËÅÉÊÈÍÛ 0 (ÈË)

                   ÐÅÃÓËßÖÈß ÈÍÒÅÐËÅÉÊÈÍÀÌÈ

   ÈË-1 - ïðîâîñïàëèòåëüûíé àãåíò, ïèðîãåí, èììóíîïîýòèí, íåéðî-

          ìåäèàòîð

   ÈË-2 - ìèòîãåí Ò-ëèìôîöèòîâ, ñòèìóëÿòîð ÅÊÊ (êèëëåðîâ)

   ÈË-3 - ãåìîïîýòèí

   ÈË-4 - â  ìàëîé êîíöåíòðàöèè ñòèìóëèðóåò ïðîäóêöèþ Ig G,  à â

          áîëüøîé êîíöåíòðàöèè - Ig E;

   ÈË-5 - èíäóöèðóåò ïðîäóêöèþ Ig A, ñòèìóëÿòîð ýîçèíîôèëîâ

   ÈË-6 - ñèíåðãèñò ÈË-1

   ÈË-7 - ãåìîïîýòèí

   ÈË-8 - õåìîàòòðàêòàíò, ðåãóëÿòîð õîìèíãà

   ÈË-9 - ãåìîïîýòèí

   ÈË-10- óíèâåðñàëüíûé   _èíãèáèòîð ñèíòåçà ìîíîêèíîâ .   (ïðîòèâî-

          âîñïàëèòåëüûíé àãåíò)

   ÈË-11- ãåìîïîýòèí

   ÈË-12- ñòèìóëÿòîð êèëëåðîê (Òê, ÅÊÊ)

   ÈË-13- ïðîòèâîâîñïàëèòåëüíûé àãåíò, ãåìîïîýòèí

   ÈË-14-

   ÈË-15- ñòèìóëÿòîð êèëëåðîâ

   ÈË-1,2,7 âëèÿþò íà ñîçðåâàíèå Ò-êëåòîê;

   ÈË-1,4,5,6 - íà ñîçðåâàíèå Â-ëèìôîöèòîâ,

    7g 0-ÈÔ è ÈË-4 - ïîâûøàþò ýêñïðåññèþ HLA II êëàññà

    7g 0-ÈÔ - Ig G2 7a 0.

   ÈË-1, ÔÍÎ-àëüôà è ÈË-6, íå ÿâëÿÿñü ñàìîñòîÿòåëüíûìè ðîñòîâûìè

ôàêòîðàìè äëÿ òèìîöèòîâ è çðåëûõ Ò-êëåòîê, ñïîñîáíû óñèëèòü ðîñ-

òîâîå äåéñòâèå ÈË-2,  ÈË-4 è ÈË-7,  ò.å.  ñëóæàò èõ êîôàêòîðàìè.

/2317ê/97/

                        2ÐÅÖÅÏÒÎÐÛ ÄËß ÈË 0

    1Ðåöåïòîðû äëÿ ÈË 0-1

   (=ÐÀÈË - ðåöåïòîðíûé àíòàãîíèñò ÈË-1)

   ÈË-1 ñòèìóëèðóåò ýêñïðåññèþ ñâîåãî ðåöåïòîðà ÷åðåç  ýíäîãåí-

íóþ ïðîäóêöèþ Pg-îâ.

   Ýôôåêòû ÐÀÈË:

   - Èíãèáèðóåò ïðîëèôåðàöèþ Ò-ëèìôîöèòîâ, èíäóöèðîâàííóþ ÈË-1

   - Áëîêèðóåò ïðîäóêöèþ ÈË-8, ÌÔÁ-1-àëüôà

   - Áëîêèðóåò ïðîòèâîâîñïàëèòåëüíóþ àêòâèíîñòü ýíäîãåííîãî ÈË-1

   - Íå èíãèáèðóåò ÀÃ-ñïåöèôè÷åñêîãî èììóíèòåòà in vivo

   - Cíèæàåò ïðîäóêöèþ êîëëàãåíàçû, àäãåçèþ ýíäîòåëèàëüíûõ êëå-

òîê ê íåéòðîôèëàì è ýîçèíîôèëàì. äåãðàäàöèþ õðÿùåâîé òêàíè, ðå-

çîðáöèþ êîñòè, ïðîäóêöèþ NO, ñèíòåç Pg E 42 0. /2460ê/95//

   Íàèáîëåå èçâåñòíûì èíãèáèòîðîì ÈË-1 ÿâëÿåòñÿ âçàèìîäåéñòâóþ-

ùèé ñ  åãî  ðåöåïòîðàìè  ÈË-1-ðåöåïòîðíûé  àãîíèñò,  ñòðóêòóðíî

áëèçêèé ê ÈË-1,  íî íå  ïåðåäàþùèé  êëåòêå  ñèãíàëà  àêòèâàöèè.

/7540/92/ ÈË-2 íåïîñðåäñòâåííî ñàì ñòèìóëèðóåò ýêñïðåññèþ ñâîå-

ãî ðåöåïòîðà. /7540/

   Èíàêòèâàöèÿ ãåíà ãàììà-öåïè,  îáùåé äëÿ  _ðåöåïòîðîâ ÈË-2,  4,

 _7,  9,  13,  15 .  ïðèâîäèò  ê  íàðóøåíèþ âñåõ âåòâåé ëèìôîïîýçà.

/2317ê/97/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

 1───────────────────────────────────────────────────────────────

 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

 1───────────────────────────────────────────────────────────────

 1ÈË-2      Ïîâûøåíèå óðîâíåé Ig G1, Ig E          Ãåìîëèòè÷åñêàÿ

                                                  1àíåìèÿ, õðîíè-

                                                  1÷åñêèé ýíòåðî-

                                                  1êîëèò

 1Áåòà-öåïü Ïîâûøåíèå óðîâíåé Ig G1, Ig E          Ãåìîëèòè÷åñêàÿ

 1ÈË-2R                                            àíåìèÿ

 1Ãàììà-öåïü Íàðóøåíèå ðàçâèòèÿ Ò- è Â-êëåòîê,

 1ÈË-2R     îòñóòñòâèå NK- è  6ïd 4+ 1-Ò-êëåòîê

 1ÈË-4      Èñ÷åçíîâåíèå Ig E, ñíèæåíèå óðîâíÿ

           1Ig G1, äåôèöèò Th2

 1ÈË-5      Îòñóòñòâèå ýîçèíîôèëîâ, äåôèöèò Th2

 1ÈË-6      Ñíèæåíèå óðîâíÿ Ig A. Íàðóøåíèå âûðà-  Ïîâðåäåíèå êîñ-

           1áîòêè îñòðîôàçíûõ áåëêîâ. Ñíèæåíèå     òåé

           1îáðàçîâàíèÿ Ig G-îòâåòà, àêòèâíîñòè

           1öèòîòîêñè÷íûõ Ò-ëèìôîöèòîâ ïðè âèðóñ-

           1íûõ èíôåêöèÿõ.

 1ÈË-10                                            Àíåìèÿ, âîñïàëè-

                                                  1òåëüíûå çàáîëå-

                                                  1âàíèÿ êèøå÷íèêà

 1ÈË-12     Îñëàáëåíèå îáðàçîâàíèÿ Òh1

 1───────────────────────────────────────────────────────────────

                     Ðåöåïòîðû ê öèòîêèíàì

                         /7272/95-ñì./

   ïîäðàçäåëÿþòñÿ íà 2 ñåìåéñòâà:  ñóïåðñåìåéñòâî Ig (Ig-ïîäîá-

íàÿ äîìåííàÿ ñòðóêòóðà) è öèòîêèíîâûå R. Âñå òðàíñìåìáðàííûå ÃÏ.

R äëÿ ÈË-1      ÈË-1          Ìîíîöèòû/ìàêðîôàãè

(öèò.R-?)                     Ëèìôîöèòû (ÅÊÊ è äð.)

Ig äîìåíû- ?                  Ãðàíóëîöèòû

                              Ýîçèíîôèëû

                              Ýíäîòåëèàëüíûå êëåòêè

                              Ãåìîïîýòè÷åñêèå êëåòêè

                              Ãåïàòîöèòû

                              Íåéðîíû

                              Õîíäðîöèòû

                              Îñòåîêëàñòû

                              Êëåòêè ñîåäèíèòåëüíîé òêàíè

                              (ôèáðîáëàñòû)

                              Òèðåîöèòû

                              Êëåòêè æèðîâîé òêàíè

                              Áåòà-êëåòêè ïîäæåëóäî÷íîé æåëåçû

- ïåðâîãî òèïà                Ò-ëèìôîöèòû

                              òèìîöèòû

                              ôèáðîáëàñòû

                              ÝÊ

                              ãåïàòîöèòû è äð.

- âòîðîãî òèïà                Â-ëèìôîöèòû

                              ìîíîöèòû

                              ìàêðîôàãàõ-?

R äëÿ ÈË-2      ÈË-2          Íà àêòèâèðîâàííûõ Ò- è Â-ëèìôîöèòàõ

(öèò.R)                       ìàêðîôàãàõ/ìîíîöèòàõ

                              ÅÊÊ

                              Ýíäîòåëèàëüíûå êëåòêè

R äëÿ ÈË-3      ÈË-3          Ïðåäøåñòâåííèêè êëåòîê êðîâè

(öèò.R)                       êðàñíîãî êîñòíîãî ìîçãà,

                              Ýîçèíîôèëû

                              ÅÊÊ

                              Ýíäîòåëèàëüíûå êëåòêè

                              Òó÷íûå êëåòêè, áàçîôèëû

R äëÿ ÈË-4      ÈË-4          Çðåëûå Ò- è Â-êëåòêè

(öèò.R)                       Ïðåäøåñòâåííèêè êëåòîê êðîâè

                              êðàñíîãî êîñòíîãî ìîçãà

                              Ôèáðîáëàñòû

                              Ýïèòåëèàëüíûå êëåòêè

                              Ýíäîòåëèàëüíûå êëåòêè

                              Ìîíîöèòû, ìàêðîôàãè

                              Ýîçèíîôèëû

                              ÅÊÊ

R äëÿ ÈË-5      ÈË-5          Ýîçèíîôèëû,

(öèò.R)                       Áàçîôèëû

                              Â-ëèìôîöèòû

                              Òèìîöèòû

R äëÿ ÈË-6      ÈË-6          Â-ëèìôîöèòû, ÏÊ

(öèò.R)                       ìèåëîìíûå êëåòêè

                              Ãåìîïîýòè÷åñêèå êëåòêè

                              ÅÊÊ

                              Ìàêðîôàãè

                              Êåðàòèíîöèòû

                              Íåéðîíû

                              Ýíäîòåëèàëüíûå êëåòêè

                              Ãåïàòîöèòû

                              Íåéòðîôèëû

R äëÿ ÈË-7      ÈË-7          Çðåëûå Ò-ëèìôîöèòû,

(öèò.R)                       Ïðåäøåñòâåííèêè ëèìôîöèòîâ

ãîìîäèìåð                     êðàñíîãî êîñòíîãî ìîçãà,

                              òèìîöèòû,

                              Ìîíîöèòû, ìàêðîôàãè

                              ÅÊÊ

R äëÿ ÈË-8      ÈË-8          Ãðàíóëîöèòû (áàçîôèëû, íåéòðîôèëû)

                              íåêîòîðûå Ò-êëåòêè,

(öåïü R 7 ðàç                 ìîíîöèòû,

ïðîíèçûâàåò                   ìèåëîìíûå êëåòêè,

ìåìáðàíó,íàïîìèíàÿ            ëèìôîöèòû

ðîäîïñèí)                     ÅÊÊ

                              Êåðàòèíîöèòû

R äëÿ ÈË-9                    Òèìîöèòû

                              Ãåìîïîýòè÷åñêèå êëåòêè

R äëÿ ÈË-10                   Ìîíîöèòû, ìàêðîôàãè

                              Ýíäîòåëèàëüíûå êëåòêè

                              Ëèìôîöèòû

R äëÿ ÈË-11                   Ãåìîïîýòè÷åñêèå êëåòêè

                              Ëèìôîöèòû (ÅÊÊ è äð.)

R äëÿ ÈË-12                   ÅÊÊ

                              Ò-õåëïåðû

R äëÿ ÈË-13                   Ìîíîöèòû, ìàêðîôàãè

                              Ãåìîïîýòè÷åñêèå êëåòêè

                              ÅÊÊ

R äëÿ ÈË-15                   ÅÊÊ

                              Ò-ëèìôîöèòû (Òê)

───────────────────────────────────────────────────────────────

                     3Êëåòêè-ìèøåíè öèòîêèíîâ

                           1/2317ê/97/

 1─────────┬─────┬──────┬──────┬────┬────┬──┬──────────┬─────────

 1Öèòîêèíû │Ìîí./│Ãðàíó-│Ýîçè- │Ò-ëô│Â-ëô│NK│Ãåìîïîýòè-│Ýíäîòåëè-

          1│ìàêð.│ëîöèòû│íîôèëû│    │    │  │÷åñêèå êë.│àëüíûå êë.

 1─────────┼─────┴──────┴──────┼────┴────┴──┼──────────┼─────────

 1ÈË-1     │  +     +      +   │àï   àïä  + │    +     │    +

 1ÈË-2     │  +                │àïä   ïä  + │          │

 1ÈË-3     │               +   │      ïä  + │    +     │

 1ÈË-4     │  +            +   │àïä  àïäè + │    +     │    +

 1ÈË-5     │        +/-    +   │     àïä    │          │

 1ÈË-6     │                   │àïä   ïä  + │    +     │

 1ÈË-7     │  +                │àïä   ïä  + │          │

 1ÈË-8     │  +     +          │ ï          │          │

 1ÈË-9     │                   │ ï          │          │

 1ÈË-10    │  +                │ ï     ä    │          │    +

 1ÈË-11    │                   │            │    +     │

 1ÈË-12    │                   │     ñ    + │          │

 1ÈË-13    │  +                │     àïäè + │    +     │

 1─────────┴───────────────────┴────────────┴──────────┴─────────

    4Ïðèìå÷àíèå: à - àêòèâàöóèÿ,

                4ï - ïðîëèôåðàöèÿ,

                4ä - äèôôåðåíöèðîâêà,

                4ñ - ñóïðåññèÿ,

                4è - ïåðåêëþ÷åíèå êëàññîâ Ig.

              1Îñíîâíûå îáëàñòè ïðèìåíåíèå öèòîêèíîâ

                            /2356ê/

────────────┬───────────────────┬──────────────────────────────

 Îáëàñòü     1│ 0     Öèòîêèíû       1│ 0    Àíòàãîíèñòû öèòîêèíîâ

 ïðèìåíåíèÿ  1│ 0                 1   │

────────────┼───────────────────┼──────────────────────────────

Âîñïàëèòåëü- 1│ 0ÈË-10, ÈË-11        1│ 0Ðàñòâîðèìûé ðåöåïòîð äëÿ ÈË-8,

íûå çàáîëå-  1│ 0                    1│ 0ÌÀÒ ïðîòèâ ÔÍÎ

âàíèÿ        1│ 0                    1│

             1│ 0                    1│ 0

Èíôåöèîííûå  1│ 0ÈË-2, ÈË-12, ÔÍÎ,   1│ 0Ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-1

çàáîëåâàíèÿ  1│ 0Ã-ÊÑÔ, Ì-ÊÑÔ,       1│ 0è ÔÍÎ,

            │ÈÔ-áåòà, ÈÔ-àëüôà   1│ 0ÈË-1-ðåöåïòîðíûé àíòàãîíèñò,

             1│ 0                    1│ 0ÈË-2-ñâÿçûâàþùèé òîêñèí,

             1│ 0                    1│ 0ÌÀÒ ïðîòèâ ÔÍÎ

             1│ 0                    1│ 0

Îíêîëîãè÷åñ- 1│ 0ÈË-1,2,3,4,9,12,13, 1│ 0ÈË-4-ñâÿçûâàþùèé ïðîòåèí,

êèå çàáîëå-  1│ 0ÔÍÎ, ÝÏÎ,           1│ 0ÌÀÒ ïðîòèâ ÈË-6,

âàíèÿ        1│ 0Ã-ÊÑÔ,Ì-ÊÑÔ,ÃÌ-ÊÑÔ,│ÈË-6-ñâÿçûâàþùèé òîêñèí

             1│ 0ÈÔ-àëüôà,ÈÔ-áåòà,   1│

             1│ 0ÈÔ-ãàììà            1│

             1│ 0                    1│ 0

Àóòîèììóííûå 1│ 0ÈÔ-áåòà             1│ 0ÈË-1-ðåöåïòîðíûé àíòåãîíèñò,

çàáîëåâàíèÿ  1│                   │ 0ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-1

             1│ 0                    1│ 0è ÔÍÎ,

             1│                   │ 0ÈË-2-àíòàãîíèñò,

             1│ 0                    1│ 0ÈË-2-ñâÿçûâàþùèé òîêñèí,

             1│                   │ 0ÌÀÒ ïðîòèâ ÔÍÎ

             1│                   │ 0

Òðàíñïëàíòà-│ÈË-3, ÈË-6,         1│ 0ÌÀÒ ïðîòèâ ÈË-2,

öèÿ êîñòíîãî 1│ 0Ã-ÊÑÔ, ÃÌ-ÊÑÔ 1      │ 0ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-4

ìîçãà, îðãà- 1│ 0                    1│ 0è ÈË-7

íîâ è òêàíåé 1│                   │

             1│                   │ 0

────────────┴───────────────────┴───────────────────────────────

               1Ñèíäðîìû, âûçûâàåìûå ïåðåäîçèðîâêîé

                      1öèòîêèíîâ /2317ê/97/

────────────┬───────────────────┬──────────────────────────────

   1Ñèíäðîìû  │Öèòîêèíû,âûçûâàþùèå│        Ïðîÿâëåíèÿ

             1│äàííûé ñèíäðîì     │

────────────┼───────────────────┼──────────────────────────────

 1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,

 1íûé         │ÈË-1,2,3;          │àäèíîìèÿ, óòîìëÿåìîñòü,

 1ñèíäðîì     │ÃÌ-ÊÑÔ, Ã-ÊÑÔ      │ìûøå÷íûå áîëè. /2317ê/97/

             1│                   │

 1Ñèíäðîì,    │ÔÍÎ-àëüôà,         │Ïàäåíèå ÀÄ,  àöèäîç,

 1ïîäîáíûé    │ÈË-1,2,6           │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,

 1ñåïòè÷åñêîìó│                   │êðîâîèçëèÿíèÿ,

 1øîêó        │                   │ëåéêîïåíèÿ,

             1│                   │ëèõîðàäêà áåç áàêòåðèåìèè.

             1│                   │/2317ê/97/

             1│                   │

 1Ñèíäðîì     │ÔÍÎ-àëüôà,         │Íàñìîðê,

 1ïðîòåêàíèÿ  │ÈË-2,              │ãèïîòåíçèÿ,

 1êàïèëëÿðîâ  │ÃÌ-ÊÑÔ,            │äèàðåÿ,

             1│ÌÀÒ ê ÑD3          │âîäÿíêà, 0  1îòåêè (îòåê ëåãêîãî),

             1│                   │æàæäà. /2317ê/97/

────────────┴───────────────────┴───────────────────────────────

.

───────────────────────────────────────────────────────────────

                          2ÈÍÒÅÐËÅÉÊÈÍÛ

                           /7273/94/                                                  89

─────┬────┬──────────┬─────────────────────────────────────────

Öèòî-│ Ì. │ Ïåðâè÷íûé│     Îñíîâíàÿ

êèíû │(êÄ)│ êëåòî÷íûé│  ô ó í ê ö è ÿ

     │    │ èñòî÷íèê │

─────┴────┴──────────┴─────────────────────────────────────────

                        + ý ô ô å ê ò û

───────────────────────────────────────────────────────────────

ÈË-1  17,5 Ìîí./ìô,    Èììóíîñòèìóëÿöèÿ, èììóíîïîýç

-àëüôà     ÅÊÊ,Â-ëèì-  Âîñïàëåíèå, ýíäîãåííûé ïèðîãåí.

-áåòà      ôîöèòû,     Îñóùåñòâëÿåò âçàèìîñâÿçü ìåæäó èììóííîé

           êëåòêè ðýñ, è íåéðîýíäîêðèííîé ñèñòåìàìè.

           àñòðîöèòû,

           ÝÊ,         Ïðåïàðàò: "áåòà-ëåéêèí"

           àêòèâèð-ûå

           íåéòðîôèëû

           /2277ê/

   Êîëè÷åñòâî ÈË-1-áåòà â ñûâîðîòêå 44%  çäîðîâûõ ëþäåé ñîñòàâ-

ëÿåò 41 _+ .6 ïã/ìë. /2272ê/95/

   Ýôôåêòû:

 1.  _Ïèðîãåí .. Ââåäåíèå ÈË-1 ïðèâîäèò ê ïîâûøåíèþ òåìïåðàòóðû òå-

    ëà, ðàçâèòèþ âàñêóëèòà, ïîâûøåíèþ ñîñóäèñòîé ïðîíèöàåìîñòè,

    ðàçâèòèþ  ÒÃÑ-ñèíäðîìà,  îñâîáîæäåíèþ àìèíîêèñëîò èç ìûøö è

    ïð. /2263ê/95/

 2.  _Íåðâíàÿ ðåãóëÿöèÿ.

    - Ãèïîòàëàìóñ (ïèðîãåííûé ýôôåêò). /2292ê/

    - Ñîí (ìåäëåííàÿ ñòàäèÿ ñíà). /2263ê/95/

 3.  _Ãîðìîíàëüíàÿ ðåãóëÿöèÿ.

   - Ñòèìóëèðóåò ãèïîòàëàìî-ãèïîôèçàðíî-íàäïî÷å÷íèêîâóþ  ñèñòå-

     ìó.  Óâåëè÷åíèå óðîâíÿ ÀÊÒÃ, êîðòèêîñòåðîèäîâ (êîðòèçîíà).

     /7759/87,2263ê/

   - Èíäóêöèÿ èíñóëèíà. /2263ê/95/

   - Óãíåòàåò ãèïîòàëàìî-ãèïîôèçàðíî-ãîíàäíóþ ñèñòåìó./7758/90/

 4. Ñòèìóëÿöèÿ  _êðàñíîãî êîñòíîãî ìîçãà .: ëåéêîöèòîç. /2263ê/95/

 5. Óñèëåíèå  ñåêðåöèè   _êîëëàãåíàçû .   ñèíîâèàëüíûìè   êëåòêàìè.

    /2292ê/

 6. Àíîðåêñèÿ. /2263ê/95/

 7. Ñòèìóëÿöèÿ  _ãåïàòîöèòîâ . (ñèíòåçà ÁÎÔ). /2292ê/

 8. Ïîäàâëåíèå àêòèâíîñòè  ëèïîïðîòåèíëèïàçû  (æèðîâàÿ  òêàíü).

    /2292ê/

 9 2. Àêòèâàöèÿ êëåòîê

   - ìàêðîôàãîâ (óñèëåíèå ïðîäóêöèè ÔÍÎ,  ÈË-6, ÔÀÒ, ËÒ, ÒÕ À2,

     Pg, àóòîêðèííàÿ àêòèâàöèÿ).

   - íåéòðîôèëîâ  (óñèëåíèå  àêêóìóëÿöèè è àêòèâàöèè)

   - Ñòèìóëÿöèÿ Ò- è Â-êëåòîê.  /2460ê/

   -- Òõ  (ñòèìóëÿöèÿ ñèíòåçà ëèìôîêèíîâ,  ñåêðåöèè ÈË-2,  ýêñ-

     ïðåññèè ðåöåïòîðîâ äëÿ ÈË-2),

   - ñòèìóëèðóåò àêòèâíîñòü Òê /2348ê/,

   - ÅÊÊ  (ÈË-1  èíäóöèðóåò  åñòåñòâåííóþ  êèëëåðíóþ àêòèâíîñòü

     /2348ê/)

   - ïîëèìîðôîíóêëåàðîâ    (ñòèìóëèðóåò   àäãåçèþ   íåéòðîôèëîâ

     /2348ê/),

   - ÝÊ. Èíäóöèðóåò ïðîêîàãóëÿíòíûå ñâîéñòâà ãðàíóëîöèòîâ è ÝÊ.

     Ïîâûøàåò ñèíòåç òêàíåâîãî ôàêòîðà, èíãèáèòîðà ïëàçìèíîãåíà

     ýíäîòåëèàëüíûìè êëåòêàìè, ñòèìóëÿöèÿ ñèíòåçà ïðîñòàãëàíäè-

     íîâ (ïðîñòàöèêëèíà-?), ÔÀÒ.

   - õîíäðîöèòîâ,

   - îñòåîêëàñòîâ,

   - ôèáðîáëàñòîâ (ðåãóëÿöèÿ ïðîòèôåðàöèè è ñåêðåòîðíîé  àêòèâ-

     íîñòè) /2292ê/,  àêòèâèðóåò ïðîëèôåðàöèþ  êëåòîê  ñîåäèíè-

     òåëüíîé òêàíè /2348ê/,

   - òèðåîöèòîâ,

   - áåòà-êëåòîê,

   - ãåïàòîöèòîâ. /2263ê/95/

       ßâëÿåòñÿ  _õåìîàòòðàêòàíòîì . äëÿ ìîíîöèòîâ, íåéòðîôèëîâ, Ò-

    è Â-ëèìôîöèòîâ,  âûçûâàåò äåãðàíóëÿöèþ íåéòðîôèëîâ ñ âûñâî-

    áîæäåíèåì ìèåëîïåðîêñèäàçû.

       Óñèëåíèå  _àäãåçèè .  (ïîâûøåíèå ýêñïðåññèè àäãåçèâíûõ ìîëå-

    êóë) ÝÊ,  íåéòðîôèëîâ,  ýîçèíîôèëîâ, áàçîôèëîâ, ìîíîöèòîâ è

    (â ìåíüøåé ñòåïåíè) ëèìôîöèòîâ. /2292ê/

10. Âëèÿåò íà ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó  _Â-ëèìôîöèòîâ . (ñòà-

    áèëèçèðóþùåå âëèÿíèå íà ïðîëèôåðàöèþ Â-ëèìôîöèòîâ è îáðàçî-

    âàíèå ÀÒ). /2292ê/

    1ÈË-1, ÔÍÎ-àëüôà è ÈË-6, íå ÿâëÿÿñü ñàìîñòîÿòåëüíûìè ðîñòîâû-

    1ìè ôàêòîðàìè äëÿ òèìîöèòîâ è çðåëûõ Ò-êëåòîê,  ñïîñîáíû óñè-

    1ëèòü ðîñòîâîå äåéñòâèå ÈË-2, èë-4 è ÈË-7, ò.å. ñëóæàò èõ êî-

    1ôàêòîðàìè. /2317ê/97/ 0 - ÏÎÂÒÎÐ

11. Ñòèìóëÿöèÿ ïðîëèôåðàöèè ÑÊÊ êîñòíîãî ìîçãà,  ãëèàëüíûõ êëå-

    òîê,  Â-ëèìôîöèòîâ, Ò-ëèìôîöèòîâ, êåðàòèíîöèòîâ6 ôèáðîáëàñ-

    òîâ, ýíäîòåëèîöèòîâ. /2460ê/95/

11. Èíäóöèðóåò  _ñèíòåç .  _ÁÎÔ,   .öèòîêèíîâ _  .(ÈË-1,2, _ÈË-3, .4,6,8,9, _  ÈÔ

    /?/ _, .  _ÔÍÎ,  ÊÑÔ . (Ã-,  Ì-,  ÃÌ-ÊÑÔ) _,  ÔÀÒ .  /?/,  Å-ñåëåêòèíà,

    ICAM-1 INCAM,  RANTES,  Pg E 42 0. /2460ê, .../ Ñèíåðãåòè÷åñêîå

    äåéñòâèå  ñ  ÔÍÎ;  ïîâûøåíèå ÷óâñòâèòåëüíîñòè êëåòîê ê ÔÍÎ.

    /2292ê/ ÈË-1 èíäóöèðóåò ñèíòåç ýïèäåðìàëüíîãî  ÔР (ôàêòîðà

    ðîñòà),  ÔÐ ôèáðîáëàñòîâ. /2348ê/ Èíäóêöèÿ ñèíòåçà àäãåçèâ-

    íûõ ôàêòîðîâ ïëàçìèíîãåííîãî àêòèâàòîðà.  /2460ê/ Ìîäóëÿöèÿ

    ýêñïðåññèè ðåöåïòîðîà äëÿ ÈË-1,  ÈË-2,  Ã-ÊÑÔ, ÃÌ-ÊÑÔ, ÔÍÎ.

    /2460ê/

12. Ñïîñîáñòâóåò àêòèâàöèè  _ôîñôîëèïàçû À2 . (ñèíòåçó Ðg E2,  Pg I

    - ? ÝÊ, ÔÀÒ). Èíäóêöèÿ ñèíòåçà ÑÎÄ ìîíîöèòàìè. /2460ê/

13. Ñòèìóëèðóåò  ïðîêîàãóëÿíòíóþ àêòèâíîñòü (âûáðîñ òðîìáîïëàñ-

    òèíà ÝÊ-ìè è ìîíîöèòàìè/ìàêðîôàãàìè). /2460ê/

13. Ðàäèîïðîòåêöèÿ.  /2263ê/95/

14. Èñïîëüçóåòñÿ äëÿ ëå÷åíèÿ îíêîëîãè÷åñêèõ çàáîëåâàíèé.  Ðàñò-

    âîðèìûå ðåöåïòîðû äëÿ ÈË-1  è  ÈË-1-ðåöåïòîðíûé  àíòàãîíèñò

    èñïîëüçóþòñÿ  äëÿ ëå÷åíèÿ èíôåêöèîííûõ è àóòîèììóííûõ çàáî-

    ëåâàíèé. /2356ê/

    _Àíòàãîíèñòû . ÈË-1:

   - ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-1,

   - ÈË-1-ðåöåïòîðíûé àíòåãîíèñò. /2356ê/

   ÐÀÈË (ðåöåïòîðíûé àíòàãîíèñò ÈË-1) áëîêèðóåò ñèíòåç  öèòîêè-

íîâ ÈË-1-àëüôà,áåòà, ÈË-8, ÔÍÎ-àëüôà. /2460ê/

               1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé

                      1öèòîêèíîâ /2317ê/97/

 1────────────┬───────────────────┬──────────────────────────────

   1Ñèíäðîìû  │Öèòîêèíû,âûçûâàþùèå│        Ïðîÿâëåíèÿ

             1│äàííûé ñèíäðîì     │

 1────────────┼───────────────────┼──────────────────────────────

 1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,

 1íûé         │ 3ÈË-1 1,2,3;          │àäèíîìèÿ, óòîìëÿåìîñòü,

 1ñèíäðîì     │ÃÌ-ÊÑÔ, Ã-ÊÑÔ      │ìûøå÷íûå áîëè. /2317ê/97/

             1│                   │

 1Ñèíäðîì,    │ÔÍÎ-àëüôà,         │Ïàäåíèå ÀÄ,  àöèäîç,

 1ïîäîáíûé    │ 3ÈË-1 1,2,6           │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,

 1ñåïòè÷åñêîìó│                   │êðîâîèçëèÿíèÿ,

 1øîêó        │                   │ëåéêîïåíèÿ,

             1│                   │ëèõîðàäêà áåç áàêòåðèåìèè.

             1│                   │/2317ê/97/

 1────────────┴───────────────────┴───────────────────────────────

.

ÈË-2 15,5  Ò-ëèìôîöèòû,Ò- è Â-ôàêòîð ðîñòà

           LGL         Àêòèâàöèÿ Ò-êëåòîê

           Ýîçèíîôèëû  è ÅÊÊ

           /2229ê/     Ïðåïàðàò - "ðîíäîëåéêèí" /?/

Ýôôåêòû:

 1. Ôàêòîð ðîñòà äëÿ Ò-õåëïåðîâ è Ò-ñóïðåññîðîâ, àêòèâèðîâàííûõ

    ÀÃ è ÈË-1, Ò-êèëëåðîâ.

 2. Ñòèìóëèðóåò ïðîëèôåðàöèþ,  äèôôåðåíöèðîâêó è ôóíêöèîíàëüíóþ

    àêòèâíîñòü Âëèìôîöèòîâ.

 3. Óñèëèâàåò ïðîäóêöèþ ÅÊÊ. Ñòèìóëèðóåò ïðîäóêöèþ 5  7b 0-ÔÍÎ.

 4. Ñòèìóëèðóåò  àíòèìèêðîáíóþ  àêòèâíîñòü  ìàêðîôàãîâ (çà ñ÷åò

    ïðîäóêöèè ðàäèêàëüíûõ ôîðì êèñëîðîäà, 7 g 0-ÈÔ, ÔÍÎ è äð.)

 5. Àêòèâèðóåò ÝÊ. Âûçûâàåò ëèçèñ ÝÊ àêòèâèðîâàííûìè ëèìôîöèòà-

    ìè --- ïîâûøåíèå ïðîíèöàåìîñòè ñîñóäèñòîé  ñòåíêè  ---  ---

    îòåê  --- àêòèâàöèÿ ãåìîñòàçà --- èøåìè÷åñêèé íåêðîç êèøå÷-

    íèêà (ïðîáîäåíèå ñèãìîâèäíîé êèøêè).

 6. Ââåäåíèå  ÈË-2  ïîëíîñòüþ  îòìåíÿåò ðàçâèòèå ïåðâè÷íîãî ÈÎ,

    ñíèæàåò âòîðè÷íûé ÈÎ, ïîâûøàåò ÷àñòîòó áàêòåðèàëüíûõ èíôåê-

    öèîííûõ îñëîæíåíèé.

 7. Èñïîëüçóåòñÿ â àäîïòèâíîé òåðàïèè ðàêà /2283ê/96/, èíôåêöè-

    îííûõ çàáîëåâàíèé.  /2356ê/ ÈË-2-àíòàãîíèñò, ÈË-2-ñâÿçûâàþ-

    ùèé  òîêñèí èñïîëüçóþòñÿ äëÿ ëå÷åíèÿ àóòîèììóííûõ çàáîëåâà-

    íèé; ÌÀÒ ïðîòèâ ÈË-2 ïðèìåíÿþòñÿ ïîñëå òðàíñïëàíòàöèè îðãà-

    íîâ; ÈË-2-ñâÿçûâþùèé òîêñèí àïðîáèðóåòñÿ äëÿ ëå÷åíèÿ èíôåê-

    öèîííûõ çàáîëåâàíèé. /2356ê/

 8. Óñèëèâàåò òîêñè÷íîñòü ìîíîöèòîâ ïðîòèâ èíôåêöèîííûõ àãåíòîâ

    è îïóõîëåâûõ êëåòîê,  ïðîäóêöèþ ñâîáîäíûõ  ôîðì  êèñëîðîäà,

    èíäóêöèþ ÈË-2-ðåöåïòîðà ãàììà-ñóáúåäèíèöû, ñèíòåç öèòîêèíîâ

    ÈË-1, ÈË-6, ÔÍÎ-àëüôà. /2460ê/95/

    _Àíòàãîíèñòû . ÈË-2:

   - ÌÀÒ ïðîòèâ ÈË-2,

   - ÈË-2-ñâÿçûâàþùèé òîêñèí,

   - ÈË-2-àíòàãîíèñò. /2356ê/98/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

 1───────────────────────────────────────────────────────────────

 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

 1───────────────────────────────────────────────────────────────

 1ÈË-2      Ïîâûøåíèå óðîâíåé Ig G1, Ig E          Ãåìîëèòè÷åñêàÿ

          Ëå÷åíèå èíôåêöèîííûõ çàáîåëâàíèé.       1àíåìèÿ, õðîíè-

          /2356ê/                                 1÷åñêèé ýíòåðî-

                                                  1êîëèò

 1Áåòà-öåïü Ïîâûøåíèå óðîâíåé Ig G1, Ig E          Ãåìîëèòè÷åñêàÿ

 1ÈË-2R                                            àíåìèÿ

 1Ãàììà-öåïü Íàðóøåíèå ðàçâèòèÿ Ò- è Â-êëåòîê,

 1ÈË-2R     îòñóòñòâèå NK- è  6ïd 4+ 1-Ò-êëåòîê

───────────────────────────────────────────────────────────────

               1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé

                      1öèòîêèíîâ /2317ê/97/

 1────────────┬───────────────────┬──────────────────────────────

   1Ñèíäðîìû  │Öèòîêèíû,âûçûâàþùèå│        Ïðîÿâëåíèÿ

             1│äàííûé ñèíäðîì     │

 1────────────┼───────────────────┼──────────────────────────────

 1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,

 1íûé         │ 3ÈË- 11, 32 1,3;          │àäèíîìèÿ, óòîìëÿåìîñòü,

 1ñèíäðîì     │ÃÌ-ÊÑÔ, Ã-ÊÑÔ      │ìûøå÷íûå áîëè. /2317ê/97/

             1│                   │

 1Ñèíäðîì,    │ÔÍÎ-àëüôà,         │Ïàäåíèå ÀÄ,  àöèäîç,

 1ïîäîáíûé    │ 3ÈË- 11, 32 1,6           │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,

 1ñåïòè÷åñêîìó│                   │êðîâîèçëèÿíèÿ,

 1øîêó        │                   │ëåéêîïåíèÿ,

             1│                   │ëèõîðàäêà áåç áàêòåðèåìèè.

             1│                   │/2317ê/97/

             1│                   │

 1Ñèíäðîì     │ÔÍÎ-àëüôà,         │Íàñìîðê,

 1ïðîòåêàíèÿ  │ 3ÈË-2 1,              │ãèïîòåíçèÿ,

 1êàïèëëÿðîâ  │ÃÌ-ÊÑÔ,            │äèàðåÿ,

             1│ÌÀÒ ê ÑD3          │âîäÿíêà,îòåêè (îòåê ëåãêîãî),

             1│                   │æàæäà. /2317ê/97/

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ÈË-3   28  Ò-ëèìôîöèòû Ãåìàòîïîýòè÷åñêèé ôàêòîð ðîñòà.

    15-18  ìàêðîôàãè   (=Ìóëüòè-ÊÑÔ - äëÿ ðàçíûõ êëåòî÷íûõ ëèíèé)

                       Ñòèìóëÿöèÿ ðîñòà è äèôôåðåíöèðîâêè ðàííèõ

                       ïðåäøåñòâåííèêîâ ìèåëîèäíûõ êëåòîê

Ýôôåêòû:

1.  _Ïîëèïîýòèí ..  /2263ê/95/ Ñòèìóëÿöèÿ ïðîëèôåðàöèè ÑÊÊ è ðàííèõ

   ïðåäøåñòâåííèêîâ Ò- è Â-êëåòîê, êåðàòèíîöèòîâ, ôèáðîáëàñòîâ,

   ýíäîòåëèîöèòîâ. /2460ê/95/ (Ýôôåêòèâíîñòü ÈË-3 ñîñòàâëÿåò 2%

   àêòèâíîñòè ÊÑÔ).  Óâåëè÷èâàåò ýêñïðåññèþ ðåöåïòîðîâ äëÿ ÊÑÔ.

   Ìîæåò  èñïîëüçîâàòüñÿ  ëäÿ  ëå÷åíèÿ   öèòîïåíèé,   ëåéêîçîâ.

   /2300ê/   ßâëÿåòñÿ ôàêòîðîì ðîñòà äëÿ Â-êëåòîê. /2460ê/

    äîçàõ  30-500  ìêã/ì 52 0 /?/ óâåëè÷èâàåò ÷èñëî ëåéêîöèòîâ â 2

   ðàçà, áàçîôèëîâ - â 8 ðàç, ýîçèíîôèëîâ - â 23. /2300ê/96/

2. Ó÷àñòâóåò â  _äèôôåðåíöèðîâêå ÒÊ .. /2460ê/

   Ñòèìóëèðóåò ôóíêöèîíàëüíóþ  àêòèâíîñòü   _áàçîôèëîâ .  (ïîâûøàåò

   ÷óâñòâèòåëüîñòü ê  Ñ3à,  ðåàêöèþ äåãðàíóëÿöèè) è òó÷íûõ êëå-

   òîê. /2263ê,2300ê/ Âûçûâàåò ïðÿìîå îñâîáîæäåíèå ãèñòàìèíà èç

   áàçîôèëîâ. /2300ê,2263ê/  Óñèëèâàåò  àëëåðãèþ.

3. Óñèëèâàåò  _ïðîäóêöèþ öèòîêèíîâ .

   - ÈË-8. /2460ê/

   - Èíäóöèðóåò ñèíòåç ÈË-1, ÔÍÎ-àëüôà. /2460ê/95/

   - àíòèãåíîâ HLA II ìàêðîôàãàìè.

   - ÈË-2R-ãàììà-ñóáúåäèíèöû. /2460ê/

4. Àêòèâèðóåò ôàãîöèòîç è ïðîäóêöèþ ñâîáîäíûõ ðàäèêàëîâ. /2460ê/

5. Óñèëèâàåò àäãåçèþ ê ýíäîòåëèþ. /2460ê/

   ÈË-3 èñïîëüçóåòñÿ äëÿ ëå÷åíèÿ  îïóõîëåâûõ  çàáîëåâàíèé  è  â

   òðàíñïëàíòîëîãèè. /2356ê/

   Ïðè  íåäîñòàòî÷íîñòè   _ÈË-3  è   ÃÌ-ÊÑÔ .   ïîðàæàþòñÿ   ëåãêèå

   /2317ê/97/;

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 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

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ÈË-3      Èñïîëüçóåòñÿ ïîñëå òðàíñïëàíòàöèè

          êðàñíîãî êîñòíîãî ìîçãà. /2356ê/

               1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé

                      1öèòîêèíîâ /2317ê/97/

 1────────────┬───────────────────┬──────────────────────────────

   1Ñèíäðîìû  │Öèòîêèíû,âûçûâàþùèå│        Ïðîÿâëåíèÿ

             1│äàííûé ñèíäðîì     │

 1────────────┼───────────────────┼──────────────────────────────

 1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,

 1íûé         │ 3ÈË 1-1,2, 33 1;          │àäèíîìèÿ, óòîìëÿåìîñòü,

 1ñèíäðîì     │ÃÌ-ÊÑÔ, Ã-ÊÑÔ      │ìûøå÷íûå áîëè. /2317ê/97/

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             ? (Òõ-2)

ÈË-4 20    Ò 4í 01 êëåòêè, Â-ôàêòîð ðîñòà (Â-êëåòî÷íî-ñòèìóëèðóþùèé

    12-20  Â-ëèìôîöèòû ôàêòîð-1),  _ñòèìóëÿöèÿ Ig E ðåàêöèé .. Ñòè-

                       ìóëÿöèÿ ïåðåêëþ÷åíèÿ Ig E è ðîñòà òó÷íûõ

                       êëåòîê.

                       Ñïîñîáñòâóåò äèôôåðåíöèðîâêå  _Òõ0 â Òõ2 ..

Ýôôåêòû:

1. Óñèëèâàåò ðîñò  Â-êëåòîê.

2. Èíäóêöèÿ íà Â-ëèìôîöèòàõ ïåðåêëþ÷åíèÿ ýêñïðåññèè ìåìáðàííîãî

   Ig Ì  _íà ìåìáðàííûé Ig E è Ig G4 .. /2263ê/ Ïîñëå óäàëåíèÿ ãåíà

   ÈË-4 ðåçêî ñíèàåòñÿ âûðàáîòêà Ig E. /2317ê/97/

   Îòñóòñòâóåò äóáëèðîâàíèå  _ÈË-4 .. Ïîñëå óäàëåíèÿ ãåíà ÈË-4 ðåç-

   êî ñíèàåòñÿ âûðàáîòêà Ig E. /2317ê/97/

   -  _Ôàêòîð ðîñòà òó÷íûõ êëåòîê .. /2263ê/.

3. Ñïîñîáñòâóåò äèôôåðåíöèðîâêå  _Òõ0 â Òõ2 .. /2300ê/

4.  _Óãíåòàåò ïðîäóêöèþ

   -  _öèòîêèíîâ .  ÈË-1,  ÈË-6, ÈË-8,

   - ÔÍÎ,

   - Pg E 42

   - ýêñïðåññèþ  äèôôåðåíöèðîâî÷íûõ ìàðêåðîâ CD 14,  CD 32,  CD

     64. /2300ê/

   - òêàíåâîãî ôàêòîðà. /2460ê/

    _Ñòèìóëÿòîð îáðàçîâàíèÿ .

   - àêòèâàòîðà ïëàçìèíîãåíà ìîíîöèòàìè.

   - ÐÀÈË (ðàñòâîðèìîãî àíòàãîíèñòà ÈË-1),

   - Ã-ÊÑÔ, ÃÌ-ÊÑÔ

   - ýêñïðåññèþ ãåíîâ ÃÊÃ I êëàññà,

   - àäãåçèâíûõ ìîëåêóë CD11/CD18  è ìàðêåðîâ CD23. /2460ê/

    4- Àíòàãîíèñò ÈË-2 Â-ëèìôîöèòîâ. Êîñòèìóëÿòîð ÈË-2 Ò-ëèìôîöèòîâ.

5. Ôàêòîð ðîñòà è ðåãóëÿòîð  _àêòèâíîñòè ÝÊ ..

7. Âûçûâàåò   _ðåçîðáöèþ  êîñòåé .,  èíäóöèðîâàííóþ  ïàðàòèðåîèäíûì

   ãîðìîíîì.

8. Èíãèáèðóåò öèòîòîêñè÷íîñòü. /2460ê/

    _Àíòàãîíèñòû . ÈË-4:

   - ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-4,

   - ÈË-4-ñâÿçûâàþùèé ïðîòåèí. /2356ê/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

 1───────────────────────────────────────────────────────────────

 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

 1───────────────────────────────────────────────────────────────

 1ÈË-4      Èñ÷åçíîâåíèå Ig E, ñíèæåíèå óðîâíÿ

           1Ig G1, äåôèöèò Th2

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ÈË-5 50-60 Ò 4í 01 êëåòêè  Ñòèìóëÿöèÿ Â-êëåòîê è ýîçèíîôèëîâ.

           /?-Òõ2-?/   Ñòèìóëÿöèÿ ïåðåêëþ÷åíèÿ íà Ig A è ýîçè-

                       íîôèëèÿ.

Ýôôåêòû:

1. Ñòèìóëèðóåò ïðîëèôåðàöèþ,  äèôôåðåíöèðîâêó è  ôóíêöèîíàëüíóþ

   àêòèâíîñòü  _ýîçèíîôèëîâ .. Ïðè èíàêòèâàöèè ãåíà ÈË-5 ðàçâèâàåò-

   ñÿ ýîçèíîôèëîïåíèÿ. /2317ê/97/

2. Ôàêòîð  _äèôôåðåíöèðîâêè . òèìîöèòîâ â öèòîòîêñè÷åñêèå  Ò-ëèìôî-

   öèòû è Â-ëèìôîöèîâ â ÀÎÊ (èíäóöèðóåò ñåêðåöèþ Ig G, Ig M, Ig

   E, Ig A). /2300ê/

3. Ïðè   èíàêòèâàöèè  ãåíà   _ÈË-5 .  ðàçâèâàåòñÿ  ýîçèíîôèëîïåíèÿ.

   /2317ê/97/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

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 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

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 1ÈË-5      Îòñóòñòâèå ýîçèíîôèëîâ, äåôèöèò Th2

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             ?

ÈË-6   26  Ò 4í 01 êëåòêè, Îáëàäàåò  _ïðîòèâîâîñïàëèòåëüíûì ñâîéñòâîì ..

           ìîí/ìàêð.,  /2460ê/95/

           ÝÊ, ôèáðî-  Ôàêòîð ðîñòà /?/ ãèáðèäîìû.

           áëàñòû,     Óñèëèâàåò êîíå÷íóþ äèôôåðåíöèðîâêó Â-ëèì-

           êëåòêè Êóï- ôîöèòîâ ( _Â-êëåòî÷íî-ñòèìóëèðóþùèé ôàêòîð .).

           ôåðà (ËÏÑ)  /2263ê/

           /7631/92/,

           Â-ëèìôîöèòû, 2 Èíäóêòîðû 0: - ìèòîãåíû Ò-êëåòîê,

           êåðàòîöèòû,             - âèðóñ Ýïøòåéíà-Áàðð,

           îñòðîâêè                - S. aureus Cowan I,

           ïîäæåëóä.               - ÈË-4 äëÿ Â-ëèìôîöèòîâ,

           æåëåçû,                 - ËÏÑ äëÿ ôèáðîáëàñòîâ,

           çëîêà÷åñò.              - áàêòåðèè è âèðóñû äëÿ

           êëåòêè                    ìàêðîôàãîâ./2317ê/97/

           /2263ê/

   Ýôôåêòû:

1. Àêòèâèðóåò ïðîëèôåðàöèþ  è äèôôåðåíöèðîâêó   _Ò-  è  Â-êëåòîê ..

   - Ôàêòîð ðîñòà Â-êëåòîê è ïîëèêëîíàëüíàÿ ïðîäóêöèÿ Ig (Ì, G,

   A). ÈË-6 ÿâëÿåòñÿ ãëàâíûì èíäóêòîðîì êîíåíîé äèôôåðåíöèðîâêè

   Â-êëåòîê. /2348ê/ Èçáûòî÷íàÿ ïðîäóêöèÿ ÈË-6 ìîæåò ïðèâåñòè ê

   çëîêà÷åñòâåííîìó ïåðåðîæäåíèþ Â-êëåòîê.  Ðåöåïòîðîâ äëÿ ÈË-6

   ìíîãî íà ìèåëîìíûõ êëåòêàõ.

   -  1ÈË-1, ÔÍÎ-àëüôà è ÈË-6, íå ÿâëÿÿñü ñàìîñòîÿòåëüíûìè ðîñòî-

    1âûìè  ôàêòîðàìè  äëÿ  òèìîöèòîâ è çðåëûõ Ò-êëåòîê,  ñïîñîáíû

    1óñèëèòü ðîñòîâîå äåéñòâèå ÈË-2,  èë-4 è ÈË-7, ò.å. ñëóæàò èõ

    1êîôàêòîðàìè. /2317ê/97/ 0 - ÏÎÂÒÎÐ Â êàêîé-òî ñòåïåíè ÈË-6 ìî-

   æåò ïîäìåíèòü ôóíêöèþ ìîíîöèòîâ/ìàêðîôàãîâ â êà÷åñòâå äîïîë-

   íèòåëüíîãî  ñèãíàëà  â  ïîääåðæàíèè  Ò-êëåòî÷íîé  àêòèâàöèè.

   /2348ê/

2.  _Ïîäàâëÿåò âûðàáîòêó

   - ÈË-1 è ÔÍÎ-àëüôà.  ßâëÿåòñÿ òèïè÷íûì ïðîòèâîâîñïàëèòåëüíûì

     öèòîêèíîì. Òîðìîæåíèå  ïðîäóêöèè   _ÔÍΠ. ïðè èíòðàòðàõåàëüíîé

     èíñòèëëÿöèè ËÏÑ. /2292ê/

      5Ñèíåðãèñò ÈË-1, ÔÍÎ. 0  5/8Ê1213-93-Èì-ÿ/ - ?

     Ïðè äåôèöèòå  _ÈË-6 è  Ì-ÊÑÔ .  ðàçâèâàåòñÿ  ïîðàæåíèå  êîñòåé

     /2317ê/97/,

4.  _Èíäóöèðóåò ñèíòåç

   - ðåöåïòîðíîãî àíòàãîíèñòà ÈË-1 è ðàñòâîðèìîãî ðåöåïòîðà äëÿ

     ÔÍÎ./2460ê/95/

   - Èíäóöèðóåò  ïðîäóêöèþ ÈË-2 è åãî ðåöåïòîðà.  --- Óñèëèâàåò

     àêòèâíîñòü ÅÊÊ. /2460ê/95/

   - Óñèëèâàåò ýêñïðåññèþ äèôôåðåíöèðîâî÷íûõ ìàðêåðîâ. /2460ê/

   - ÀÃ HLA I êëàññà& /2460ê/

   - óñèëèâàåò  ïðîäóêöèþ  íåñïåöèôè÷åñêèõ  ýñòåðàç,  ëèçîöèìà.

     /2460ê/

   - ðåöåïòîðà äëÿ Ì-ÊÑÔ /2460ê/

   - ïðîäóêöèþ ÐÀÈË /2460ê/

   - ðåöåïòîðà äëÿ ÔÍÎ /2460ê/

   - Èíäóöèðóåò ñèíòåç ÁÎÔ, êîðòèêîòðîïèíà è ÔÐÍ. /2460ê/  _Ãåïà-

      _òîöèò .-ñòèìóëèðóþùèé ôàêòîð.  Èíäóöèðóåò ñèíòåç ÁÎÔ ãåïàòî-

     öèòàìè ïå÷åíè ïðè âîçäåéñòâèè ÈË-1.  Âûçûâàåò òðàíñêðèïöèþ

     ìÐÍÊ Ñ-ÐÁ. /2348ê/

     ßâëÿåòñÿ ìîùíûì ñòèìóëîì òàêîé ñèñòåìíîé ðåàêöèè, êàê îñò-

     ðîôàçíûé  îòâåò íà òêàíåâîå ïîâðåæäåíèå (òðàâìà èëè èíôåê-

     öèÿ).  /2348ê/  _Óðîâåíü ïîâûøàåòñÿ ïðè âîñïàëåíèè .. /8Ê1212-

     93-Èì-ÿ/ Ìîáèëèçàöèÿ  _íåéòðîôèëîâ â î÷àãè âîñïàëåíèÿ .. /2292ê/

     Óñèëèâàåò ôàãîöèòîç. /2460ê/

     Èíäóöèðóåò  _àïîïòîç íåéòðîôèëîâ .. /2460ê/95/

     Ó ìûøåé ñ äåôåêòíûì ãåíîì ÈË-6 íàðóøåíà  ïðîäóêöèÿ  îñòðî-

     ôàçíûõ áåëêîâ,  ñíèæåí òèòð ñïåöèôè÷åñêèõ èììóíîãëîáóëèíîâ

     G è Òê ïðè èíôåöèè, âûçâàííîé âèðóñîì âåçèêóëÿðíîãî ñòîìà-

     òèòà,  ïîâûøåíà  ÷óâñòâèòåëüíîñòü ê ëèñòåðèÿì (äåôåêò Òê).

     /2460ê/

   - Óñèëåíèå ñåêðåöèè  _ÀÊÒà.. /2292ê/

4.  _Àêòèâàöèÿ ÝÊ . (ñèíòåç ôàêòîðà ðîñòà  òðîìáîöèòîâ),  ïîâûøåíèå

   ïðîíèöàåìîñòè. /2292ê/

7. -  _Ñèíåðãèñò ÈË-3 . (ðåãóëèðóåò ãåìîïîýç òðîìáîöèòîâ, àêòèâèðó-

     åò ïåðåõîä ìåãàêàðèîöèòîâ â òðîìáîöèòû). /8Ê1213-93-Èì-ÿ/

   - Àêòèâèðóåò ïðîëèôåðàöèþ  _ñòâîëîâûõ êëåòîê . è èíäóöèðóåò ñèí-

     òåç Ã- è ÃÌ-ÊÑÔ. /2460ê/95/

    5- Èíãèáèðóåò ïðîëèôåðàöèþ /2460ê/ 0- ?

   - Èíäóöèðóåò ñîçðåâàíèå ìåãàêàðèîöèòîâ è îñòåîáëàñòîâ. /2460ê/

   - Ñòèìóëèðóåò  ðîñò  ìåçàíãèàëüíûõ  êëåòîê,  êåðàòèíîöèòîâ è

     äèôôåðåíöèðîâêó íåéðîíîâ, êëåòîê-ïðåäøåñòâåííèêîâ ãðàíóëî-

     öèòîâ è ìàêðîôàãîâ. /2460ê/95/

13. Èíãèáèðóåò ïðîëèôåðàöèþ  _ìàêðîôàãîâ . è óñèëèâàåò èõ äèôôåðåí-

    öèðîâêó. /2460ê/95/

   Èçáûòî÷íàÿ  ïðîäóêöèÿ ÈË-6 ìîæåò ïðèâåñòè ê ðàçâèòèþ àóòîèì-

   ìóííûõ çàáîëåâàíèé.

    _Àíòàãîíèñòû . ÈË-6:

   - ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-7,

   - ÈË-6-ñâÿçûâàþùèé òîêñèí. /2356ê/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

 1───────────────────────────────────────────────────────────────

 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

 1───────────────────────────────────────────────────────────────

 1ÈË-6      Ñíèæåíèå óðîâíÿ Ig A. Íàðóøåíèå âûðà-  Ïîâðåäåíèå êîñ-

           1áîòêè îñòðîôàçíûõ áåëêîâ. Ñíèæåíèå     òåé

           1îáðàçîâàíèÿ Ig G-îòâåòà, àêòèâíîñòè

           1öèòîòîêñè÷íûõ Ò-ëèìôîöèòîâ ïðè âèðóñ-

           1íûõ èíôåêöèÿõ.

          Èñïîëüçóåòñÿ ïîñëå òðàíñïëàíòàöèè

          êðàñíîãî êîñòíîãî ìîçãà. /2356ê/

 1───────────────────────────────────────────────────────────────

               1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé

                      1öèòîêèíîâ /2317ê/97/

 1────────────┬───────────────────┬──────────────────────────────

   1Ñèíäðîìû  │Öèòîêèíû,âûçûâàþùèå│        Ïðîÿâëåíèÿ

             1│äàííûé ñèíäðîì     │

 1────────────┼───────────────────┼──────────────────────────────

 1Ñèíäðîì,    │ÔÍÎ-àëüôà,         │Ïàäåíèå ÀÄ,  àöèäîç,

 1ïîäîáíûé    │ 3ÈË 1-1,2, 36 1           │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,

 1ñåïòè÷åñêîìó│                   │êðîâîèçëèÿíèÿ,

 1øîêó        │                   │ëåéêîïåíèÿ,

             1│                   │ëèõîðàäêà áåç áàêòåðèåìèè.

             1│                   │/2317ê/97/

 1────────────┴───────────────────┴───────────────────────────────

.

ÈË-7 25  Còðîìàëüíûå   _Ëèìôîïîýòèí . äëÿ ïðî-Â-êëåòîê,

           êëåòêè êð. ëèìôîöèòàðíûé ôàêòîð ðîñòà - óñèëèâàåò

           êîñòíîãî   ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó Ò-ëèôîöèòîâ

           ìîçãà è    â Òõ è Òñ.

           òèìóñà

           çàðîäûøà,

           Ò-ëèìôîöèòû

   Ýôôåêòû:

1. Ðåãóëèðóåò ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó Ò- è  Â-ëèìôîöèòîâ

   (èíäóöèðóåò ýêñïðåññèþ ðåöåïòîðîâ ê ÈË-2, òðàíñôåððèíó).

   Îòêëþ÷åíèå ãåíà  _ÈË-7 . ïðèâîäèò ê íàðóøåíèþ âñåõ âåòâåé ëèìôî-

   ïîýçà. /2317ê/97/

2. Ïîâûøàåò öèòîòîêñè÷íîñòü âî êëåòîê CTL è NK.

3. Àêòèâèðóåò è ñòèìóëèðóåò ìîíîöèòû. /2300ê/

4. Óñèëèâàåò ïðîòèâîîïóõîëåâóþ àêòèâíîñòü. /2460ê/

.

ÈË-8  8,8  Ìîí./ìàêð.,  _Õåìîàòòðàêòàíò .û íåéòðîôèëîâ, Ò-ëèìôîöè-

       │   ÝÊ, ëèìôî-  òîâ, ìîíîöèòîâ. /2263ê/

      6,5  öèòû,ôèáðî- Ðåãóëÿöèÿ õîìèíãà ëèìôîöèòîâ è èíôèëüò-

     (àêò. áëàñòû,çëî- ðàöèè íåéòðîôèëîâ.

    ôîðìà) êà÷åñòâåí-

           íûå êëåòêè

   Ñèíòåç ÈË-8 ñòèìóëèðóåòñÿ â ýíäîòåëèàëüíûõ êëåêòêàõ  òðîìáè-

   íîì. /2250ê/96/

   Ýôôåêòû:

1. Ñòèìóëèðóåò

   - õåìîòàêñèñ íåéòðîôèëîâ è Ò-ëèìôîöèòîâ /2300ê/

   -- àêêóìóëÿöèÿ  íåéòðîôèëîâ  â  î÷àã  âîñïàëåíèÿ  (ëîêàëüíîå

      äåéñòâèå); ÈË-8 àêòèâèðóåò äâèãàòåëüíûé  àïïàðàò  êëåòîê,

      íàïðàâëåíèå ìèãðàöèè, ýêñïðåññèþ ìîëåêóë àäãåçèè /2348ê/;

   -- ïîäàâëåíèå ýìèãðàöèè íåéòðîôèëîâ ïðè âíóòðèâåííîì  ââåäå-

      íèè (ñèñòåìíûé ýôôåêò). /2292ê/

   - àäãåçèþ íåéòðîôèëîâ,

   - àêòèâèðóåò âûáðîñ íåéòðîôèëàìè ôåðìåíòîâ è  àêòèâíûõ  ôîðì

     êèñëîðîäà. /2300ê,2348ê/

2. Ñòèìóëèðóåò  äåãðàíóëÿöèþ áàçîôèëîâ (âûáðîñ ãèñòàìèíà è ëåé-

   êîòðèåíà).

3. Èíäóöèðóåò ëîêîìîöèþ ÈË-2-àêòèâèðîâàííûõ åñòåñòâåííûõ êèëëå-

   ðîâ.

4. Óñèëèâàåò

   - ìîáèëèçàöèþ âíóòðèêëåòî÷íîãî êàëüöèÿ /2460ê/

   - Àêòâèðóåò ïðîäóêöèþ ÔÀÒ. /2460ê/95/

   - ýêñïðåññèþ  I  òèïà ðåöåïòîðà äëÿ êîìïëåìåíòà è

   - ýêñïðåññèþ  àäãåçèâíûõ  ìîëåêóë  CD11/CD18   ãðàíóëîöèòîâ.

     /2460ê/95/

5. Ñòèìóëèðóåò õåìîòàêñèñ Ò-ëèìôîöèòîâ. /2460ê/95/

6. Ñòèìóëèðóåò ïðîëèôåðàöèþ êåðàòèíîöèòîâ. /2460ê/95/

7. Óñèëèâàåò  àäãåçèâíîñòü ìîíîöèòîâ ê ÝÊ /2460ê/ Óñèëèâàåò àí-

   ãèîãåíåç. /2460ê/95/

8. Àêòèâèðóåò   _äåãðàíóëÿöèþ .,  âûõîä  ëèçîñîìàëüíûõ   ôåðìåíòîâ,

   ðåñïèðàòîðíûé âçðûâ /2460ê/

    _Àíòàãîíèñòû . ÈË-8:

   - ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-8. /2356ê/

    _Ðåöåïòîðû íà

   - íåéòðîôèëàõ,

   - Ò-ëèìôîöèòàõ, à òàêæå íà

   - òðàíñôîðìèðîâàííûõ  êëåòêàõ ìèåëîìîíîöèòàðíîãî ïðîèñõîæäå-

íèÿ ÍL-60. /2326ê/97/

.

ÈË-9 ð40   Àêòèâèðî-   Ò-êëåòî÷íûé ôàêòîð ðîñòà, ñòèìóëÿòîð

           âàííûå Ò-   ãåìàòîïîýçà.

           ëèìôîöèòû

   Ýôôåêòû:

1. Ðåãóëèðóåò  ïðîëèôåðàöèþ  òèìîöèòîâ.  Âìåñòå ñ ÈË-2 ïîâûøàåò

   ïðîëèôåðàöèþ ôåòàëüíûõ òèìîöèòîâ.

2. Ñòèìóëèðóåò  ïðîëèôåðàöèþ  ïðåäøåñòâåííèêîâ ýðèòðîèäíûõ êëå-

   òîê.

.

ÈË-10  18  Â- è Ò 4í 02-  Èììóíîñóïðåññèâíûé è ïðîòèâîâîñïàëèòåëü-

     28-35 ëèìôîöèòû, íûé öèòîêèí. /7591/93/

           òèìîöèòû,  Óíèâåðñàëüíûé  _èíãèáèòîð ñèíòåçà ìîíîêè .-

           ÒÊ, ÌÍÔ     _íîâ .)

                      Àêòèâàòîð Ò-êèëëåðîâ è òèìîöèòîâ.

                      Äåéñòâèå íà Ò-, Â-êëåòêè, ÒÊ, èíãèáèòîð

                      Ò 4í 01 (ñèíòåçà öèòîêèíîâ),

   ÈË-10 ãîìîëîãè÷åí  ñ EBV-áåëêàìè.

Ýôôåêòû:

1.  _Èììóíîñóïðåññîð ., ïîäàâëÿþùèé ôóíêöèè ìîíîöèòîâ è ìàêðîôàãîâ.

   Áëîêèðóåò  äåéñòâèå  ðàííèõ ïðîâîñïàëèòåëüíûõ ìåäèàòîðîâ ïðè

   ñåïòè÷åñêîì øîêå (ËÏÑ,  ÔÍÎ).  Èíãèáèöèÿ  ñèíòåçà  öèòîêèíîâ

   Ò-õåëïåðàìè è ìàêðîôàãàìè.  /?/ Èíãèáèðóåò  ïðîäóêöèþ  ÈË-2.

   Èíãèáèðóåò ïðåäñòàâëåíèå  ÀÃ ìàêðîôàíàìè,  ñíèæàÿ ýêñïðåññèþ

   Àà II ÃÊÃ,  ñíèæàåò ýêñïðåññèþ Ò-êëåòî÷íîãî àíòèãåííîãî  ðå-

   öåïòîðà, ðåöåïòîðà äëÿ ÈË-2. /2460ê/95/

2. Ï _ðîòèâîâîñïàëèòåëüíûé öèòîêèí ..  /7591/93/

    _Ïîäàâëÿåò îáðàçîâàíèå

   - ÈË-1, ÈË-3, ÈË-6,  ÈË-8, ÈË-12 /?/

   - ÃÌ-ÊÑÔ, Ã-ÊÑÔ, Ì-ÊÑÔ

   - ÔÍÎ /2460ê/95/, ÈË-10 óñèëèâàåò øåääèíã sTNF-R ñ ìîíîöèòîâ

     êðîâè /2461ê/

   - áëîêèðóåò  ïðîäóêöèþ ÒÔÐ.  /2461ê/

   - ÈË-2 /?/.

   - Ïîäàâëÿåò ýêñïðåññèþ àíòèãåíîâ II êëàññà. /2300ê/

   - òêàíåâîãî ôàêòîðà /2460ê/

   - ÈÔ-àëüôà,ãàììà (Òõ-ìè)

   - ñóïåðîêñèäíûõ è íèòðîêñèäíûõ ðàäèêàëîâ àêòèâèðîâàííûìè ìî-

     íîöèòàìè,

   - ïîâåðõíîñòíûõ äèôôåðåíöèðîâî÷íûõ ìàðêåðîâ

   - ïðîäóêöèþ HLA II è ÈË-1 ìàêðîôàãàìè.

   _Àêòèâèðóåò ïðîäóêöèþ

  - ÐÀÈË (ðåöåïòîðíîãî àíòàãîíèñòà ÈË-1). /2460ê/

2. Ôàêòîð äèôôåðåíöèðîâêè Ò-êèëëåðîâ.  /?/ Èíãèáèðóåò  öèòîòîê-

   ñè÷íîñòü /2460ê/95/

3. Ïðîëèôåðàöèÿ  çðåëûõ è íåçðåëûõ òèìîöèòîâ â ïðèñóòñòâèè ÈË-2

   è ÈË-4;

- Ñíèæàåò   ïðîëèôåðàöèþ   Ò-ëèìôîöèòîâ,   èíäóöèðîâàííóþ   àí-

òè-CD-23-ÀÒ, ÈË-1, ÈË-6, ÔÍÎ. /2460ê/95/

4. Ñòèìóëÿöèÿ òó÷íûõ êëåòîê ïðè êîìáèíàöèè ñ ÈË-3 è/èëè ÈË-4;

5. Âìåøàòåëüñòâî (ïîìåõà-?) â ïðîöåññ ïðåçåíòàöèè ÀÃ.

6. Óñèëèâàåò ñèíòåç Ig M  è  Ig E.

7.  5Àëüôà-ÔÍÎ àêòèâèðóåò  NO-ñèíòåòàçó,  âûçûâàþùåé  îáðàçîâàíèå

    5NO-ðåàêòèâíûõ  ìåòàáîëèòîâ.   0ÈË-10  èíãèáèðóåò NO-ñèíòåòàçó.

   /2294ê/95/

8. Ïðåäîòâðàùàåò àïîïòîç  _Â-ëèìôîöèòîâ .. Óñèëèâàåò àòèâàöèþ, ïðî-

   ëèôåðàöèþ  è  äèôôåðåíöèðîâêó  Â-ëèìôîöèòîâ,  èíäóöèðîâàííóþ

   ÈË-2  è àíòè-Ig M-àíòèòåëàìè.  Óñèëèâàåò ïðîäóêöèþ Ig M è Ig

   E.  Óñèëèâàåò ýêñïðåññèþ ïîâåðõíîñòíûõ ÀÃ Â-ëèìôîöèòîâ è ÒÊ.

   /2460ê/95/

9. Ïðåäîòâðàùàåò ðàçâèòèå äèàáåòà. /2460ê/95/

10.Èíãèáèðóåò êèëëèíã  ïàðàçèòîâ ìàêðîôàãàìè,  ÿâëÿåòñÿ ïåðìåñ-

   ñèâíûì äëÿ ðîñòà ìèêðîáíûõ ïàòîãåíîâ  è  îïóõîëåâûõ  êëåòîê.

   /2460ê/95/

    _Ïðè  óäàëåíèè  ÈË-10  ïîðàæàåòñÿ  êèøå÷íèê. /2317ê/97/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

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 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

 1───────────────────────────────────────────────────────────────

 1ÈË-10      0Ïðîòèâîâîñïàëèòåëüíûé àãåíò 1            Àíåìèÿ, âîñïàëè-

                                                  1òåëüíûå çàáîëå-

                                                  1âàíèÿ êèøå÷íèêà

 1───────────────────────────────────────────────────────────────

.

ÈË-11  23  Ñòðîìàëü-   Êîôàêòîð  _ãåìîïîýçà .;

           íûå êëåòêè  Â-êëåòî÷íûé ôàêòîð ðîñòà;

           êîñòíîãî    ðåãóëÿòîð çàäåðæêè êëåòî÷íîãî öèêëà;

           ìîçãà       ñòèìóëÿòîð ÅÊÊ; àêòèâàòîð Ò-êèëëåðîâ.

   Ýôôåêòû:

1. Ñèíåðãèñò ÈË-6.

2. Ñòèìóëÿöèÿ ñèíòåçà Ig G â ïðèñóòñòâèè Ò-êëåòîê.

3. Ñòèìóëÿöèÿ ìåãàêàðèîöèòîâ.

4. Ïðîòèâîâîñïàëèòåëüíûé öèòîêèí. /2356ê/

.

ÈË-12 75 Ìàêðîôàãè,    Ñòèìóëÿöèÿ ÅÊÊ, àêòèâàöèÿ Ò- _êèëëåðîâ

ð40-ð35  Â-ëèìôîöèòû,  (óñèëèâàåò êëåòî÷íûé ÈÎ).

         íåéòðîôèëû,   Ñèíòåçèðóåòñÿ ÀÏÊ --- ïåðåêëþ÷åíèå Òõ0 íà

         äåíäðèòíûå    Òõ1.

         êëåòêè

   Ïðîäóöèðóåòñÿ â îñíîâíîì ìàêðîôàãàìè  è  â  ìåíüøåé  ñòåïåíè

äðóãèìè ÀÏÊ â îòâåò íà Àà áàêòåðèé è âíóòðèêëåòî÷íûõ ïàðàçèòîâ.

/2460ê/95/

   Ýôôåêòû:

1. Ôàêòîð ðîñòà àêòèâèðîâàííûõ Ò-ëèìôîöèòîâ (CD4+ è CD8+),  ÅÊÊ

   (CD 56),  óñèëèâàåò ýôôåêò ÈË-2.  Ñòèìóëÿöèÿ öèòîòîêñè÷íîñòè

   ÅÊÊ.  Ôàêòîð ñîçðåâàíèÿ êèëëåðîâ (ÅÊÊ,Ò).  Èíäóöèðóåò äèôôå-

   ðåíöèðîâêó ÖÒË.

2. Ñòèìóëÿöèÿ Òõ1, òîðìîæåíèå ñèíòåçà Ig E, àêòèâèðîâàííóþ ÈË-4

   è ãàììà-ÈÔ-îì. 4 Ñïîñîáñòâóåò ðàçâèòèþ Òõ êëàññà 1. /2460ê/95/

   Ó÷àñòâóåò â  ïðîëèôåðàöèè è äèôôåðåíöèðîâêå Ò-ëèìôîöèòîâ (ïå-

   ðåâîäå Òõ0 â Òõ1).  ÈË-12 ÿâëÿåòñÿ âûðàæåííûì èíãèáèòîðîì ïå-

   ðåõîäà Òõ0 â Òõ2. /2460ê/

3. Ñòèìóëÿöèÿ ëèìôîöèòàðíîé àêòèâíîñòè

   - Óñèëèâàåò ïðîëèôåðàöèþ ëèìôîöèòîââ îòâåò àí ìèòîãåíû

   - Èíäóöèðóåò ïðîäóêöèþ ÈÔ-ãàììà Ò-ëèìôîöèòàìè

   - Ñòèìóëèðóåò ëèìôîêèí-àêòèâèðîâàííûå êèëëåðû

   - Ïîòåíöèðóåò äåéñòâèå ÈË-2 íà ïðîëèôåðàöèþ ëèìôîöèòîâ

   - Àêòèâèðóåò  ÅÊÊ.  Èíäóöèðóåò   ñèíòåç   öèòîêèíîâ   ÈÔ-ãàììà,

     ÔÍÎ-àëüôà, ÔÍÎ-áåòà ÅÊÊ-ìè.

   - Óñèëèâàåò äåéñòâèå âàêöèíû ïðîòèâ ëåéøìàíèîçà

4. Óñèëèâàåò ýêñïðåññèþ ïîâåðõíîñòíûõ ÀÃ, ìîëåêóë àäãåçèè è ðå-

   öåïòîðîâ:  CD56,  CD2,  ICAM-1,  LFA-1,  áåòà-  è ãàììà-öåïè

   ÈË-2-ðåöåïòîðà, 75 êÄ-ðåöåïòîð äëÿ ÔÍÎ.

5. Óâåëè÷èâàåò óðîâíü NO, ïðîäóêöèþ õåìîòàêñèíîâ. /2634ê/99/

6 4. Ñèíåðãèçì ñ ÈË-2 â îòíîøåíèè öèòîòîêñè÷íîñòè ëèìôû /?/ è ãå-

    4íåðàöèè LAK (ïîäîáíûå Òê).

7. Ââåäåíèå ÈË-12 ìîæåò âûçâàòü èììóíîòîêñè÷åñêèé ýôôåêò,  ñâÿ-

çàííûé ÷àñòè÷íî  ñ ïðîäóêöèåé ïðîâîñïàëèòåëüíûõ öèòîêèíîâ (ãàì-

ìà-ÈÔ è äð.).

   Ò.î., âàæíåéøåå ñâÿçóþùåå çâåíî ìåæäó ñïåöèôè÷åñêîé è íåñïå-

öèôè÷åñêàîé çàùèòîé.

   Ñèíåðãèñòû - ÈË-8, ÈË-2;

   Àíòàãîíèñò - ÈË-10. /2634ê/99/

    1 óñëîâèÿõ  áëîêàäû Òõ1 ïðîäóêòàìè Òõ2 âíóòðèêëåòî÷íûå ïàðà-

 1çèòû, íàïðèìåð,  Toxoplasma gondii,  ìîãóò èíäóöèðîâàòü  ñèíòåç

 1ìàêðîôàãàìè åùå  îäíîãî öèòîêèíà - ÈË-12,  êîòîðûé ìîæåò çàïóñ-

 1òèòü Ò-íåçàâèñèìûé ñèíòåç ÈÔ-ãàììà ÅÊÊ-ìè. ÈË-10 down-ðåãóëèðó-

 1åò ïðîäóêöèþ ÈË-12,  ìàêðîôàãàìè,  íî è ÈË-12 ñî ñâîåé ñòîðîíû,

 1èíãèáèðóÿ äèôôåðåíöèðîâêó Òõ2,  ìîæåò áëîêèðîâàòü ñèíòåç ÈË-10.

 1Òàêèì îáðàçîì,  ÈË-10 è ÈË-12 îêàçûâàþò àíòàãîíèñòè÷åñêîå äåéñ-

 1òâèå íà ýôôåêòèâíîñòü êëåòî÷íîé çàùèòû.  Îò  ïðåîáëàäàíèÿ  òîãî

 1èëè èíîãî èç ýòèõ öèòîêèíîâ ìîãóò çàâèñåòü èñõîä èíôåêöèè è ýô-

 1ôåêòèâíîñòü ïðîòèâîîïóõîëåâîé çàùèòû. /2461ê/

4. Èíäóöèðóåò ïðîäóêöèþ ãàììà-ÈÔ Ò-ëèìôîöèòàìè.  Óñèëèâàåò ïðî-

ëèôåðàöèþ ëèìôîöèòîâ â îòâåò íà ìèòîãåíû.  Ïîòåíöèðóåò äåéñòâè-

åÈË-2. /2460ê/95/

- Óñèëèâàåò äåéñòâèå âàêöèíû ïðîòèâ ëåéøìàíèîçà.  /2460ê/95/

              1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ

                  1èëè èõ ðåöåïòîðîâ /2317ê/97/

 1───────────────────────────────────────────────────────────────

 1Öèòîêèí, │        Îæèäàåìûå ïîñëåäñòâèÿ         │ Íåîæèäàííûå

 1ðåöåïòîðû│                                      │ ïîñëåäñòâèÿ

 1───────────────────────────────────────────────────────────────

 1ÈË-12     Îñëàáëåíèå îáðàçîâàíèÿ Òh1

          Ëå÷åíèå èíôåöèîííûõ çàáîëåâàíèé. /2356ê/

 1───────────────────────────────────────────────────────────────

.

ÈË-13  9-  Ò-ëèìôîöèòû  _Ïðîòèâîâîñïàëèòåëüíûé àãåíò

       17  (Òõ2)

   Ýôôåêòû:

1. Ïðîòèâîâîñïàëèòåëüíûé àãåíò

    _Ñòèìóëÿöèÿ ñèíòåçà

   - ðåöåïòîðíîãî àíòàãîíèñòà ÈË-1 (ÐÀÈË);

    _Ïîäàâëÿåò îáðàçîâàíèå . ïðîâîñïàëèòåëüíûõ öèòîêèíîâ. Ïî õàðàê-

   òåðó âëèÿíèÿ î÷åíü áëèçîê ê ÈË-4. /2461ê/

   - ÈË-1, ÈË-6,

   - ÔÍÎ

    5Èíäóêöèÿ ï-ÈÔ ïðîäóêöèè ÐÂ2, Ò- è ÅÊÊ ÈË-6, ÈË-1, ÔÍÎ. - ???

2. Ñòèìóëèðóåò ïðîëèôåðàöèþ  _ñòâîëîâûõ êëåòîê ., äèôôåðåíöèðîâêó

   ìîíîöèòîâ. /2300ê/

3. Õåìîàòòðàêòîð äëÿ ìîíîöèòîâ.

4. Èíãèáèðóåò ïðîòèâîïàðàçèòàðíóþ àêòèâíîñòü, òîêñè÷íîñòü, ìàê-

   ðîôàã-ñâÿçàííóþ èììóíîñóïðåññèþ. /2460ê/

.

ÈË-15

   Ýôôåêòû:

1. Àêòèâèðóåò ÅÊÊ, ïðîëèôåðàöèþ Ò-ëèìôîöèòîâ, èõ äèôôåðåíöèðîâ-

   êó â Òê.  /2460ê/ Èíèöèèðóåò îáðàçîâàíèå ëèìôîêèíàêòèâèðîâàí-

   íûõ êèëëåðîâ. /2460ê/95/

───────────────────────────────────────────────────────────────

Ïðèìå÷àíèå: ÝÊ - ýíäîòåëèàëüíûå êëåòêè

            ðýñ - ðåòèêóëîýíäîòåëèàëüíàÿ ñèñòåìà

            ÔÍÎ - ôàêòîð íåêðîçà îïóõîëåé

            ÈÔ - èíòåðôåðîí

            ÅÊÊ - åñòåñòâåííûå êëåòêè-êèëëåðû

            Pg - ïðîñòàãëàíäèíû

            ÔÀÒ - ôàêòîð àêòèâàöèè òðîìáîöèòîâ

.

  Oppenheimer-Marks N.  Brezinschek RI.  Mohamadzadeh M.  Vita R.  Lipsky

  PE.

   _Interleukin 15 . is produced by endothelial cells and increases the

  transendothelial migration of T cells In vitro and in the SCID mouse-human

  rheumatoid arthritis model In vivo.

Source

  Journal of Clinical Investigation.  101(6):1261-72, 1998 Mar 15.

The capacity of endothelial cells (EC) to produce IL-15 and the capacity

  of IL-15 to influence transendothelial migration of T cells was examined.

  Human umbilical vein endothelial cells expressed both IL-15 mRNA and

  protein. Moreover, endothelial-derived IL-15 enhanced transendothelial

  migration of T cells as evidenced by the inhibition of this process by

  blocking monoclonal antibodies to IL-15. IL-15 enhanced transendothelial

  migration of T cells by activating the binding capacity of the integrin

  adhesion molecule LFA-1 (CD11a/CD18) and also increased T cell motility.

  In addition, IL-15 induced expression of the early activation molecule

  CD69. The importance of IL-15 in regulating migration of T cells in vivo

  was documented by its capacity to enhance accumulation of adoptively

  transferred human T cells in rheumatoid arthritis synovial tissue

  engrafted into immune deficient SCID mice. These results demonstrate that

  EC produce IL-15 and imply that endothelial IL-15 plays a critical role in

  stimulation of T cells to extravasate into inflammatory tissue.

  Lantero S.  Sacco O.  Scala C.  Rossi GA.

  Stimulation of blood mononuclear cells of atopic children with the

  relevant allergen induces the release of eosinophil chemotaxins such as

   _IL-3, IL-5, and GM-CSF.

  Journal of Asthma.  34(2):141-52, 1997.

Peripheral blood mononuclear cells (PBMC) from 10 atopic asthmatic

  children (atopics), sensitized to Dermatophagoides pteronyssinus (Dp), and

  from 5 nonatopic healthy children (controls) were stimulated with Dp

  extract or with birch extract (Be). After 6 days we tested the

  supernatant's (Sn) chemotactic activity toward purified blood

  eosinbnophils and T-lymphocyte proliferation. Dp induced a statistically

  significant T-cell proliferation from atopics as compared to controls (p <

  0.05), which correlated with the levels of eosinophil chemotactic activity

  in the Sn (r = 0.713; p < 0.05). Measurable levels of IL-3, IL-5, and

  GM-CSF were demonstrated in the Sn of Dp-stimulated PBMC from atopics,

  while eosinophil locomotion toward different concentrations of recombinant

  human (rh) IL-3, rhIL-5, and rhGM-CSF confirmed that these cytokines were

  able to stimulate eosinophil chemotaxis in a close concentration range.

  Preincubation of different concentrations of the same Sn with blocking

  antisera demonstrated that anti-human (ah) IL-3, ahIL-5, and ahGM-CSF

  effectively decreased eosinophil chemotaxis (p < 0.05; each comparison).

  Thus PBMC activation with the relevant allergen induces the release by T

  cells with a Th2 phenotype of chemotactic factors for eosinophils.

  Ogawa M.  Tsutsui T.  Zou JP.  Mu J.  Wijesuriya R.  Yu WG.  Herrmann S.

  Kubo T.  Fujiwara H.  Hamaoka T.

  Enhanced induction of very late antigen 4/lymphocyte function-associated

   _antigen 1-dependent T-cell migration to tumor sites following

   _administration of interleukin 12.

   Cancer Research.  57(11):2216-22, 1997 Jun 1.

Administration of interleukin 12 (IL-12) into mice bearing CSA1M, OV-HM,

  Meth A, or MCH-1-A1 tumor induced complete regression of CSA1M and OV-HM

  tumors but induced only a slight growth inhibition of Meth A and MCH-1-A1

  tumors. These effects of IL-12 were associated with high and only marginal

  levels of T-cell infiltration into CSA1M/OV-HM and Meth A/MCH-1-A1 tumor

  masses, respectively. Here, we investigated the role of IL-12 in the

  induction of T-cell migration. Spleen cells from untreated or

  IL-12-treated CSA1M-bearing mice were stained in vitro with a fluorescein

  chemical and transferred i.v. into IL-12-untreated CSA1M-bearing mice.

  Migration of donor cells was quantitated by counting the number of

  fluorescent cells on cryostat sections of tumor masses. Although only a

  slight migration was detected for spleen cells from IL-12-untreated

  CSA1M-bearing as well as IL-12-treated or untreated normal mice, enhanced

  migration was observed for cells from IL-12-treated CSA1M-bearing mice. A

  similar enhanced migration was observed for the OV-HM model. In contrast,

  such an enhancement was only marginal in the Meth A and MCH-1-A1 models.

  Immunohistochemical studies of tumors from IL-12-treated mice revealed

  that the predominant T-cell subset was CD4+ in CSA1M and CD8+ in OV-HM

  tumor masses. Consistent with this observation, the dominant subset of

  migrating T cells was found to be CD4+ in the CSA1M and CD8+ in the OV-HM

  models. T-cell migration was inhibited by pretreatment of recipients with

  either combination of anti-very late antigen 4 + anti-vascular cell

  adhesion molecule 1 or anti-lymphocyte function-associated antigen 1 +

  anti-intercellular adhesion molecule 1 monoclonal antibody. These results

  indicate that IL-12 can confer T cells with a capacity to migrate to tumor

  sites through very late antigen 4/lymphocyte function-associated antigen 1

  adhesion pathways and that the in vivo acquisition of such a capacity

  following IL-12 treatment correlates with the induction of tumor

  regression.

  Marth T.  Strober W.  Seder RA.  Kelsall BL.

  Regulation of transforming growth factor-beta production by

  interleukin-12.

Source

  European Journal of Immunology.  27(5):1213-20, 1997 May.

The induction of peripheral tolerance following oral antigen

  administration in several autoimmune disease and conventional animal

  models correlates with the production of transforming growth factor-beta

  (TGF-beta) and T helper type 2 (Th2) cytokines. The factors regulating

  TGF-beta production and its relation to the Th2 response, however, have

  not been defined. We demonstrate that the systemic administration of

  antibodies to interleukin (IL)-12 to ovalbumin (OVA)-T cell receptor (TCR)

  transgenic mice fed high doses of OVA, followed by systemic OVA challenge,

  substantially enhances TGF-beta, but not IL-4 production by peripheral T

  cells. Furthermore, we demonstrate in an in vitro T cell differentiation

  model that naive (CD4+/Mel-14hi) OVA-TCR-T cells stimulated with

  OVA-pulsed dendritic cells (DC) produce four- to fivefold higher amounts

  of TGF-beta when cultured with anti-IL-12 or anti-interferon-gamma

  (IFN-gamma). In this in vitro system, IL-4 was not required for TGF-beta

  production by T cells; however, it appeared to enhance levels of TGF-beta

  by promoting the growth of TGF-beta-producing cells. Our findings

  demonstrate that IL-12 and IFN-gamma are important negative regulators of

  TGF-beta production both in vivo and in vitro, and that their modulation

  may be of benefit for the treatment of autoimmune disorders.

  Stern AS.  Magram J.  Presky DH.

Institution

  Hoffmann-La Roche Inc. Nutley, NJ 07110-1199, USA.

Title

  Interleukin-12 an integral cytokine in the immune response. [Review] [147

  refs]

Source

  Life Sciences.  58(8):639-54, 1996.

Interleukin 12 (IL-12) is a heterodimeric cytokine that is produced

  primarily by antigen-presenting cells and plays a primary role in the

  induction of cell-mediated immunity. This function is promoted by the

  IL-12 induced production of interferon-gamma (IFN-gamma) from both resting

  and activated NK and T cells, by the proliferative activity of IL-12 on

  activated NK and T cells, by enhancing the cytotoxic activity of NK cells,

  and by supporting cytotoxic T lymphocyte generation. IL-12 and

  IL-12-induced IFN-gamma promote the development of naive T cells into Th1

  cells and the proliferation and IFN-gamma secretion by differentiated Th1

  cells in response to antigen. IL-12 has been found to exhibit many of

  these activities in vivo, as well as in vitro, and thus IL-12 plays an

  important role in both innate resistance and antigen-specific adaptive

  immunity to intracellular bacterial, fungal, and protozoan pathogens. Due

  to its effects on T cells, recombinant IL-12 has been shown to have

  therapeutic activity in a variety of mouse tumor and infectious disease

  models and is being evaluated in clinical trials in human cancer patients.

  IL-12 also appears to play a role in the genesis of some forms of

  immunopathology, including endotoxin-induced shock and some autoimmune

  diseases associated with aberrant Th1 activity. Therefore, IL-12

  antagonists may also have therapeutic potential in the treatment of auto

  immune disorders. [References: 147]

  Li C.  Goodrich JM.  Yang X.

  Interferon-gamma (IFN-gamma) regulates production of IL-10 and IL-12 in

  human herpesvirus-6 (HHV-6)-infected monocyte/macrophage lineage.

  Clinical & Experimental Immunology.  109(3):421-5, 1997 Sep.

      To determine whether HHV-6 infection induces expression and production of

  IL-10 and IL-12 in monocytes/macrophages, and to explore the influence of

  IFN-gamma on cytokine production in HHV-6-infected cells, expression and

  production of IL-10 and IL-12 were evaluated through reverse

  transcription-polymerase chain reaction (RT-PCR) and sandwich ELISA. HHV-6

  infection induced the expression and the production of IL-10 and IL-12 in

  monocytes and THP-1 cells. Kinetic study showed that the expression of

  IL-12 mRNA decreased with accumulation of IL-10 mRNA. Expression and

  production of IL-12 were markedly increased when anti-human IL-10 MoAbs

  were added to the cultures, implying that endogenous IL-10 induced by

  HHV-6 inhibited IL-12 production. Addition of increasing concentrations of

  IFN-gamma to the cultures of HHV-6-infected cells enhanced the expression

  of IL-12 gene, while the accumulation of IL-10 mRNA was down-regulated.

  Determination of protein levels of IL-10 and IL-12 by ELISA also showed

  that IFN-gamma increased IL-12 and decreased IL-10 production. These

  results suggest that IFN-gamma regulates the production of IL-10 and IL-12

  at transcriptional level mainly through inhibiting endogenous IL-10

  production in HHV-6-infected monocyte/macrophage lineage.

  Mielcarek M.  Graf L.  Johnson G.  Torok-Storb B.

  Production of interleukin-10 by granulocyte colony-stimulating

  factor-mobilized blood products: a mechanism for monocyte-mediated

  suppression of T-cell proliferation.

  Blood.  92(1):215-22, 1998 Jul 1.

        Previous reports showed that granulocyte colony-stimulating factor

  (G-CSF)-mobilized peripheral blood mononuclear cells (G-PBMC) are

  hyporesponsive to alloantigen compared with control PBMC. In the current

  study,  _neutralizing antibodies to interleukin-10 (IL-10) . increased the

  proliferative response of G-PBMC to alloantigen by 50. 14% (+/- 12.79%; n

  = 8), whereas the proliferative response of control PBMC was not affected.

  The inhibition of OKT3-stimulated CD4 cell proliferation by G-PBMC-derived

  CD14(+) cells could also be abrogated by the addition of IL-10

  neutralizing antibodies. Further, IL-10 levels correlated with the number

  of CD14 cells in these cultures. Constitutive IL-10 mRNA levels detected

  by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)

  were 10-fold higher in G-PBMC compared with control PBMC. This translated

  into significantly higher IL-10 levels after 24-hour lipopolysaccharide

  (LPS) stimulation of G-PBMC compared with control PBMC (P = .036). IL-10

  mRNA levels were also fivefold higher in isolated G-PBMC-derived CD14

  cells compared with control CD14 cells. This corresponded to increased

  constitutive production of IL-10 by isolated G-PBMC-derived CD14 cells

  compared with control CD14 cells (357.2 +/- 104.5 v 51.7 +/- 30.5, P =

  .051). In conclusion, these data suggest that monocytes contained within

  G-PBMC, which, in comparison to marrow, are increased in absolute number

  and relative proportion to T cells, may suppress T-cell responsiveness by

  secretion of IL-10.

  Rohde T.  MacLean DA.  Richter EA.  Kiens B.  Pedersen BK.

  Prolonged submaximal eccentric exercise is associated with increased

  levels of plasma IL-6.

  American Journal of Physiology.  273(1 Pt 1):E85-91, 1997 Jul.

  To study the relationship between exercise-related muscle proteolysis and

  the cytokine response, a prolonged eccentric exercise model of one leg was

  used. Subjects performed two trials [a branched-chain amino acid (BCAA)

  supplementation and a control trial]. The release of amino acids from

  muscle during and after the eccentric exercise was decreased in the BCAA

  trial, suggesting a suppression of net muscle protein degradation. The

  plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19

  (preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control

  trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/-

  1.21 pg/ml. Eccentric exercise had no effect on the concentrations of

  neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte

  proliferative response, or cytotoxic activities. BCAA supplementation

  reduced the concentration of CD14+/CD38+ cells. This study shows that the

  concentration of IL-6 in plasma is increased after prolonged eccentric

  exercise and suggests that the cytokine response is independent of the

  muscle proteolysis that occur during exercise.

  Venkatraman JT.  Pendergast D.

  Effects of the level of dietary fat intake and endurance exercise on

  plasma cytokines in runners.

  Medicine & Science in Sports & Exercise.  30(8):1198-204, 1998 Aug.

  PURPOSE:Chronic exercise and high fat diets have been associated with

  immune suppression. We have reported the effects of level of dietary fat

  and exercise on lymphocyte subsets, proliferative response, and in vitro

  production of cytokines by peripheral blood mononuclear cells of runners.

  The present study was planned to further investigate whether the

  mechanisms of action of dietary fats is through their modulation of plasma

  cytokines in runners. METHODS: This study compared plasma cytokines at

  rest and after endurance exercise at 80% of V02max in female (N = 8-10)

  and male (N = 8-10) runners after eating diets comprised of 17% (LF), 32%

  (MF), and 41% (HF) fats (4 wk each). RESULTS: The level of interleukin-1

  beta (IL-1 beta) was independent of gender, exercise, and level of dietary

  fat. tumor necrosis factor (TNF-alpha) level was higher in the plasma of

  men compared with that in women runners, and the level of these two

  cytokines increased with increasing level of dietary fat. Plasma

  interleukin-2 (IL-2) level (a cytokine involved in enhancing T cell

  functions for host defense) was significantly higher in men compared with

  that in women runners and decreased in men with increase dietary fat.

  Plasma interleukin-6(IL-6) level was significantly lower after the

  endurance run, and IL-6 levels decreased with increase in dietary fat.

  CONCLUSIONS: Data from the present study suggest that dietary fat has

  differential effects on plasma cytokine levels in runners. Increasing the

  level of dietary fat significantly increased endurance run time and had no

  adverse effects on the level of plasma IL-2 and pro-inflammatory cytokines

  (IL-1 beta, IL-6 and TNF-alpha in runners.

ÝÏÎ-? .                        2ÈÍÒÅÐËÅÉÊÈÍÛ 0 (ÈË)                    ÐÅÃÓËßÖÈß ÈÍÒÅÐËÅÉÊÈÍÀÌÈ    ÈË-1 - ïðîâîñïàëèòåëüûíé àãåíò, ïèðîãåí, èììóíîïîýòèí, íåéðî-           ìåäèàòîð    ÈË-2 - ìèòîãåí Ò-ëèìôîöèòîâ, ñòèìóëÿòîð ÅÊÊ (êèëëåðî

 

• 14:21 05 Èþëÿ 2016
  Ðîññèéñêî-êèòàéñêèé ìåäóíèâåðñèòåò îòêðîåò ìàãèñòåðñêóþ ïðîãðàììó ïî TCM
• 01:21 05 Èþëÿ 2016
  Íà ôîðóìå ÌÃÓ Ðîññèÿ è Êèòàé îáñóäÿò íàó÷íî-îáðàçîâàòåëüíîå ñîòðóäíè÷åñòâî
• 11:00 04 Èþëÿ 2016
  Ðåìîðåíêî: "ÅÃÝ-òóðèçì" â Ðîññèè ñõîäèò íà íåò
• 10:52 04 Èþëÿ 2016
  Ëåòíÿÿ ðîññèéñêî-àâñòðèéñêàÿ øêîëà îòêðîåòñÿ â Ìîñêâå
• 15:31 01 Èþëÿ 2016
   ÑÏáÃÓ ìîãóò âîññîçäàòü ãåîãðàôè÷åñêèé ôàêóëüòåò

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