êóðñîâûå,êîíòðîëüíûå,äèïëîìû,ðåôåðàòû
ÝÏÎ-?
.
2ÈÍÒÅÐËÅÉÊÈÍÛ 0 (ÈË)
ÐÅÃÓËßÖÈß ÈÍÒÅÐËÅÉÊÈÍÀÌÈ
ÈË-1 - ïðîâîñïàëèòåëüûíé àãåíò, ïèðîãåí, èììóíîïîýòèí, íåéðî-
ìåäèàòîð
ÈË-2 - ìèòîãåí Ò-ëèìôîöèòîâ, ñòèìóëÿòîð ÅÊÊ (êèëëåðîâ)
ÈË-3 - ãåìîïîýòèí
ÈË-4 - â ìàëîé êîíöåíòðàöèè ñòèìóëèðóåò ïðîäóêöèþ Ig G, à â
áîëüøîé êîíöåíòðàöèè - Ig E;
ÈË-5 - èíäóöèðóåò ïðîäóêöèþ Ig A, ñòèìóëÿòîð ýîçèíîôèëîâ
ÈË-6 - ñèíåðãèñò ÈË-1
ÈË-7 - ãåìîïîýòèí
ÈË-8 - õåìîàòòðàêòàíò, ðåãóëÿòîð õîìèíãà
ÈË-9 - ãåìîïîýòèí
ÈË-10- óíèâåðñàëüíûé _èíãèáèòîð ñèíòåçà ìîíîêèíîâ . (ïðîòèâî-
âîñïàëèòåëüûíé àãåíò)
ÈË-11- ãåìîïîýòèí
ÈË-12- ñòèìóëÿòîð êèëëåðîê (Òê, ÅÊÊ)
ÈË-13- ïðîòèâîâîñïàëèòåëüíûé àãåíò, ãåìîïîýòèí
ÈË-14-
ÈË-15- ñòèìóëÿòîð êèëëåðîâ
ÈË-1,2,7 âëèÿþò íà ñîçðåâàíèå Ò-êëåòîê;
ÈË-1,4,5,6 - íà ñîçðåâàíèå Â-ëèìôîöèòîâ,
7g 0-ÈÔ è ÈË-4 - ïîâûøàþò ýêñïðåññèþ HLA II êëàññà
7g 0-ÈÔ - Ig G2 7a 0.
ÈË-1, ÔÍÎ-àëüôà è ÈË-6, íå ÿâëÿÿñü ñàìîñòîÿòåëüíûìè ðîñòîâûìè
ôàêòîðàìè äëÿ òèìîöèòîâ è çðåëûõ Ò-êëåòîê, ñïîñîáíû óñèëèòü ðîñ-
òîâîå äåéñòâèå ÈË-2, ÈË-4 è ÈË-7, ò.å. ñëóæàò èõ êîôàêòîðàìè.
/2317ê/97/
2ÐÅÖÅÏÒÎÐÛ ÄËß ÈË 0
1Ðåöåïòîðû äëÿ ÈË 0-1
(=ÐÀÈË - ðåöåïòîðíûé àíòàãîíèñò ÈË-1)
ÈË-1 ñòèìóëèðóåò ýêñïðåññèþ ñâîåãî ðåöåïòîðà ÷åðåç ýíäîãåí-
íóþ ïðîäóêöèþ Pg-îâ.
Ýôôåêòû ÐÀÈË:
- Èíãèáèðóåò ïðîëèôåðàöèþ Ò-ëèìôîöèòîâ, èíäóöèðîâàííóþ ÈË-1
- Áëîêèðóåò ïðîäóêöèþ ÈË-8, ÌÔÁ-1-àëüôà
- Áëîêèðóåò ïðîòèâîâîñïàëèòåëüíóþ àêòâèíîñòü ýíäîãåííîãî ÈË-1
- Íå èíãèáèðóåò ÀÃ-ñïåöèôè÷åñêîãî èììóíèòåòà in vivo
- Cíèæàåò ïðîäóêöèþ êîëëàãåíàçû, àäãåçèþ ýíäîòåëèàëüíûõ êëå-
òîê ê íåéòðîôèëàì è ýîçèíîôèëàì. äåãðàäàöèþ õðÿùåâîé òêàíè, ðå-
çîðáöèþ êîñòè, ïðîäóêöèþ NO, ñèíòåç Pg E 42 0. /2460ê/95//
Íàèáîëåå èçâåñòíûì èíãèáèòîðîì ÈË-1 ÿâëÿåòñÿ âçàèìîäåéñòâóþ-
ùèé ñ åãî ðåöåïòîðàìè ÈË-1-ðåöåïòîðíûé àãîíèñò, ñòðóêòóðíî
áëèçêèé ê ÈË-1, íî íå ïåðåäàþùèé êëåòêå ñèãíàëà àêòèâàöèè.
/7540/92/ ÈË-2 íåïîñðåäñòâåííî ñàì ñòèìóëèðóåò ýêñïðåññèþ ñâîå-
ãî ðåöåïòîðà. /7540/
Èíàêòèâàöèÿ ãåíà ãàììà-öåïè, îáùåé äëÿ _ðåöåïòîðîâ ÈË-2, 4,
_7, 9, 13, 15 . ïðèâîäèò ê íàðóøåíèþ âñåõ âåòâåé ëèìôîïîýçà.
/2317ê/97/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-2 Ïîâûøåíèå óðîâíåé Ig G1, Ig E Ãåìîëèòè÷åñêàÿ
1àíåìèÿ, õðîíè-
1÷åñêèé ýíòåðî-
1êîëèò
1Áåòà-öåïü Ïîâûøåíèå óðîâíåé Ig G1, Ig E Ãåìîëèòè÷åñêàÿ
1ÈË-2R àíåìèÿ
1Ãàììà-öåïü Íàðóøåíèå ðàçâèòèÿ Ò- è Â-êëåòîê,
1ÈË-2R îòñóòñòâèå NK- è 6ïd 4+ 1-Ò-êëåòîê
1ÈË-4 Èñ÷åçíîâåíèå Ig E, ñíèæåíèå óðîâíÿ
1Ig G1, äåôèöèò Th2
1ÈË-5 Îòñóòñòâèå ýîçèíîôèëîâ, äåôèöèò Th2
1ÈË-6 Ñíèæåíèå óðîâíÿ Ig A. Íàðóøåíèå âûðà- Ïîâðåäåíèå êîñ-
1áîòêè îñòðîôàçíûõ áåëêîâ. Ñíèæåíèå òåé
1îáðàçîâàíèÿ Ig G-îòâåòà, àêòèâíîñòè
1öèòîòîêñè÷íûõ Ò-ëèìôîöèòîâ ïðè âèðóñ-
1íûõ èíôåêöèÿõ.
1ÈË-10 Àíåìèÿ, âîñïàëè-
1òåëüíûå çàáîëå-
1âàíèÿ êèøå÷íèêà
1ÈË-12 Îñëàáëåíèå îáðàçîâàíèÿ Òh1
1───────────────────────────────────────────────────────────────
Ðåöåïòîðû ê öèòîêèíàì
/7272/95-ñì./
ïîäðàçäåëÿþòñÿ íà 2 ñåìåéñòâà: ñóïåðñåìåéñòâî Ig (Ig-ïîäîá-
íàÿ äîìåííàÿ ñòðóêòóðà) è öèòîêèíîâûå R. Âñå òðàíñìåìáðàííûå ÃÏ.
R äëÿ ÈË-1 ÈË-1 Ìîíîöèòû/ìàêðîôàãè
(öèò.R-?) Ëèìôîöèòû (ÅÊÊ è äð.)
Ig äîìåíû- ? Ãðàíóëîöèòû
Ýîçèíîôèëû
Ýíäîòåëèàëüíûå êëåòêè
Ãåìîïîýòè÷åñêèå êëåòêè
Ãåïàòîöèòû
Íåéðîíû
Õîíäðîöèòû
Îñòåîêëàñòû
Êëåòêè ñîåäèíèòåëüíîé òêàíè
(ôèáðîáëàñòû)
Òèðåîöèòû
Êëåòêè æèðîâîé òêàíè
Áåòà-êëåòêè ïîäæåëóäî÷íîé æåëåçû
- ïåðâîãî òèïà Ò-ëèìôîöèòû
òèìîöèòû
ôèáðîáëàñòû
ÝÊ
ãåïàòîöèòû è äð.
- âòîðîãî òèïà Â-ëèìôîöèòû
ìîíîöèòû
ìàêðîôàãàõ-?
R äëÿ ÈË-2 ÈË-2 Íà àêòèâèðîâàííûõ Ò- è Â-ëèìôîöèòàõ
(öèò.R) ìàêðîôàãàõ/ìîíîöèòàõ
ÅÊÊ
Ýíäîòåëèàëüíûå êëåòêè
R äëÿ ÈË-3 ÈË-3 Ïðåäøåñòâåííèêè êëåòîê êðîâè
(öèò.R) êðàñíîãî êîñòíîãî ìîçãà,
Ýîçèíîôèëû
ÅÊÊ
Ýíäîòåëèàëüíûå êëåòêè
Òó÷íûå êëåòêè, áàçîôèëû
R äëÿ ÈË-4 ÈË-4 Çðåëûå Ò- è Â-êëåòêè
(öèò.R) Ïðåäøåñòâåííèêè êëåòîê êðîâè
êðàñíîãî êîñòíîãî ìîçãà
Ôèáðîáëàñòû
Ýïèòåëèàëüíûå êëåòêè
Ýíäîòåëèàëüíûå êëåòêè
Ìîíîöèòû, ìàêðîôàãè
Ýîçèíîôèëû
ÅÊÊ
R äëÿ ÈË-5 ÈË-5 Ýîçèíîôèëû,
(öèò.R) Áàçîôèëû
Â-ëèìôîöèòû
Òèìîöèòû
R äëÿ ÈË-6 ÈË-6 Â-ëèìôîöèòû, ÏÊ
(öèò.R) ìèåëîìíûå êëåòêè
Ãåìîïîýòè÷åñêèå êëåòêè
ÅÊÊ
Ìàêðîôàãè
Êåðàòèíîöèòû
Íåéðîíû
Ýíäîòåëèàëüíûå êëåòêè
Ãåïàòîöèòû
Íåéòðîôèëû
R äëÿ ÈË-7 ÈË-7 Çðåëûå Ò-ëèìôîöèòû,
(öèò.R) Ïðåäøåñòâåííèêè ëèìôîöèòîâ
ãîìîäèìåð êðàñíîãî êîñòíîãî ìîçãà,
òèìîöèòû,
Ìîíîöèòû, ìàêðîôàãè
ÅÊÊ
R äëÿ ÈË-8 ÈË-8 Ãðàíóëîöèòû (áàçîôèëû, íåéòðîôèëû)
íåêîòîðûå Ò-êëåòêè,
(öåïü R 7 ðàç ìîíîöèòû,
ïðîíèçûâàåò ìèåëîìíûå êëåòêè,
ìåìáðàíó,íàïîìèíàÿ ëèìôîöèòû
ðîäîïñèí) ÅÊÊ
Êåðàòèíîöèòû
R äëÿ ÈË-9 Òèìîöèòû
Ãåìîïîýòè÷åñêèå êëåòêè
R äëÿ ÈË-10 Ìîíîöèòû, ìàêðîôàãè
Ýíäîòåëèàëüíûå êëåòêè
Ëèìôîöèòû
R äëÿ ÈË-11 Ãåìîïîýòè÷åñêèå êëåòêè
Ëèìôîöèòû (ÅÊÊ è äð.)
R äëÿ ÈË-12 ÅÊÊ
Ò-õåëïåðû
R äëÿ ÈË-13 Ìîíîöèòû, ìàêðîôàãè
Ãåìîïîýòè÷åñêèå êëåòêè
ÅÊÊ
R äëÿ ÈË-15 ÅÊÊ
Ò-ëèìôîöèòû (Òê)
───────────────────────────────────────────────────────────────
3Êëåòêè-ìèøåíè öèòîêèíîâ
1/2317ê/97/
1─────────┬─────┬──────┬──────┬────┬────┬──┬──────────┬─────────
1Öèòîêèíû │Ìîí./│Ãðàíó-│Ýîçè- │Ò-ëô│Â-ëô│NK│Ãåìîïîýòè-│Ýíäîòåëè-
1│ìàêð.│ëîöèòû│íîôèëû│ │ │ │÷åñêèå êë.│àëüíûå êë.
1─────────┼─────┴──────┴──────┼────┴────┴──┼──────────┼─────────
1ÈË-1 │ + + + │àï àïä + │ + │ +
1ÈË-2 │ + │àïä ïä + │ │
1ÈË-3 │ + │ ïä + │ + │
1ÈË-4 │ + + │àïä àïäè + │ + │ +
1ÈË-5 │ +/- + │ àïä │ │
1ÈË-6 │ │àïä ïä + │ + │
1ÈË-7 │ + │àïä ïä + │ │
1ÈË-8 │ + + │ ï │ │
1ÈË-9 │ │ ï │ │
1ÈË-10 │ + │ ï ä │ │ +
1ÈË-11 │ │ │ + │
1ÈË-12 │ │ ñ + │ │
1ÈË-13 │ + │ àïäè + │ + │
1─────────┴───────────────────┴────────────┴──────────┴─────────
4Ïðèìå÷àíèå: à - àêòèâàöóèÿ,
4ï - ïðîëèôåðàöèÿ,
4ä - äèôôåðåíöèðîâêà,
4ñ - ñóïðåññèÿ,
4è - ïåðåêëþ÷åíèå êëàññîâ Ig.
1Îñíîâíûå îáëàñòè ïðèìåíåíèå öèòîêèíîâ
/2356ê/
────────────┬───────────────────┬──────────────────────────────
Îáëàñòü 1│ 0 Öèòîêèíû 1│ 0 Àíòàãîíèñòû öèòîêèíîâ
ïðèìåíåíèÿ 1│ 0 1 │
────────────┼───────────────────┼──────────────────────────────
Âîñïàëèòåëü- 1│ 0ÈË-10, ÈË-11 1│ 0Ðàñòâîðèìûé ðåöåïòîð äëÿ ÈË-8,
íûå çàáîëå- 1│ 0 1│ 0ÌÀÒ ïðîòèâ ÔÍÎ
âàíèÿ 1│ 0 1│
1│ 0 1│ 0
Èíôåöèîííûå 1│ 0ÈË-2, ÈË-12, ÔÍÎ, 1│ 0Ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-1
çàáîëåâàíèÿ 1│ 0Ã-ÊÑÔ, Ì-ÊÑÔ, 1│ 0è ÔÍÎ,
│ÈÔ-áåòà, ÈÔ-àëüôà 1│ 0ÈË-1-ðåöåïòîðíûé àíòàãîíèñò,
1│ 0 1│ 0ÈË-2-ñâÿçûâàþùèé òîêñèí,
1│ 0 1│ 0ÌÀÒ ïðîòèâ ÔÍÎ
1│ 0 1│ 0
Îíêîëîãè÷åñ- 1│ 0ÈË-1,2,3,4,9,12,13, 1│ 0ÈË-4-ñâÿçûâàþùèé ïðîòåèí,
êèå çàáîëå- 1│ 0ÔÍÎ, ÝÏÎ, 1│ 0ÌÀÒ ïðîòèâ ÈË-6,
âàíèÿ 1│ 0Ã-ÊÑÔ,Ì-ÊÑÔ,ÃÌ-ÊÑÔ,│ÈË-6-ñâÿçûâàþùèé òîêñèí
1│ 0ÈÔ-àëüôà,ÈÔ-áåòà, 1│
1│ 0ÈÔ-ãàììà 1│
1│ 0 1│ 0
Àóòîèììóííûå 1│ 0ÈÔ-áåòà 1│ 0ÈË-1-ðåöåïòîðíûé àíòåãîíèñò,
çàáîëåâàíèÿ 1│ │ 0ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-1
1│ 0 1│ 0è ÔÍÎ,
1│ │ 0ÈË-2-àíòàãîíèñò,
1│ 0 1│ 0ÈË-2-ñâÿçûâàþùèé òîêñèí,
1│ │ 0ÌÀÒ ïðîòèâ ÔÍÎ
1│ │ 0
Òðàíñïëàíòà-│ÈË-3, ÈË-6, 1│ 0ÌÀÒ ïðîòèâ ÈË-2,
öèÿ êîñòíîãî 1│ 0Ã-ÊÑÔ, ÃÌ-ÊÑÔ 1 │ 0ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-4
ìîçãà, îðãà- 1│ 0 1│ 0è ÈË-7
íîâ è òêàíåé 1│ │
1│ │ 0
────────────┴───────────────────┴───────────────────────────────
1Ñèíäðîìû, âûçûâàåìûå ïåðåäîçèðîâêîé
1öèòîêèíîâ /2317ê/97/
────────────┬───────────────────┬──────────────────────────────
1Ñèíäðîìû │Öèòîêèíû,âûçûâàþùèå│ Ïðîÿâëåíèÿ
1│äàííûé ñèíäðîì │
────────────┼───────────────────┼──────────────────────────────
1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,
1íûé │ÈË-1,2,3; │àäèíîìèÿ, óòîìëÿåìîñòü,
1ñèíäðîì │ÃÌ-ÊÑÔ, Ã-ÊÑÔ │ìûøå÷íûå áîëè. /2317ê/97/
1│ │
1Ñèíäðîì, │ÔÍÎ-àëüôà, │Ïàäåíèå ÀÄ, àöèäîç,
1ïîäîáíûé │ÈË-1,2,6 │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,
1ñåïòè÷åñêîìó│ │êðîâîèçëèÿíèÿ,
1øîêó │ │ëåéêîïåíèÿ,
1│ │ëèõîðàäêà áåç áàêòåðèåìèè.
1│ │/2317ê/97/
1│ │
1Ñèíäðîì │ÔÍÎ-àëüôà, │Íàñìîðê,
1ïðîòåêàíèÿ │ÈË-2, │ãèïîòåíçèÿ,
1êàïèëëÿðîâ │ÃÌ-ÊÑÔ, │äèàðåÿ,
1│ÌÀÒ ê ÑD3 │âîäÿíêà, 0 1îòåêè (îòåê ëåãêîãî),
1│ │æàæäà. /2317ê/97/
────────────┴───────────────────┴───────────────────────────────
.
───────────────────────────────────────────────────────────────
2ÈÍÒÅÐËÅÉÊÈÍÛ
/7273/94/ 89
─────┬────┬──────────┬─────────────────────────────────────────
Öèòî-│ Ì. │ Ïåðâè÷íûé│ Îñíîâíàÿ
êèíû │(êÄ)│ êëåòî÷íûé│ ô ó í ê ö è ÿ
│ │ èñòî÷íèê │
─────┴────┴──────────┴─────────────────────────────────────────
+ ý ô ô å ê ò û
───────────────────────────────────────────────────────────────
ÈË-1 17,5 Ìîí./ìô, Èììóíîñòèìóëÿöèÿ, èììóíîïîýç
-àëüôà ÅÊÊ,Â-ëèì- Âîñïàëåíèå, ýíäîãåííûé ïèðîãåí.
-áåòà ôîöèòû, Îñóùåñòâëÿåò âçàèìîñâÿçü ìåæäó èììóííîé
êëåòêè ðýñ, è íåéðîýíäîêðèííîé ñèñòåìàìè.
àñòðîöèòû,
ÝÊ, Ïðåïàðàò: "áåòà-ëåéêèí"
àêòèâèð-ûå
íåéòðîôèëû
/2277ê/
Êîëè÷åñòâî ÈË-1-áåòà â ñûâîðîòêå 44% çäîðîâûõ ëþäåé ñîñòàâ-
ëÿåò 41 _+ .6 ïã/ìë. /2272ê/95/
Ýôôåêòû:
1. _Ïèðîãåí .. Ââåäåíèå ÈË-1 ïðèâîäèò ê ïîâûøåíèþ òåìïåðàòóðû òå-
ëà, ðàçâèòèþ âàñêóëèòà, ïîâûøåíèþ ñîñóäèñòîé ïðîíèöàåìîñòè,
ðàçâèòèþ ÒÃÑ-ñèíäðîìà, îñâîáîæäåíèþ àìèíîêèñëîò èç ìûøö è
ïð. /2263ê/95/
2. _Íåðâíàÿ ðåãóëÿöèÿ.
- Ãèïîòàëàìóñ (ïèðîãåííûé ýôôåêò). /2292ê/
- Ñîí (ìåäëåííàÿ ñòàäèÿ ñíà). /2263ê/95/
3. _Ãîðìîíàëüíàÿ ðåãóëÿöèÿ.
- Ñòèìóëèðóåò ãèïîòàëàìî-ãèïîôèçàðíî-íàäïî÷å÷íèêîâóþ ñèñòå-
ìó. Óâåëè÷åíèå óðîâíÿ ÀÊÒÃ, êîðòèêîñòåðîèäîâ (êîðòèçîíà).
/7759/87,2263ê/
- Èíäóêöèÿ èíñóëèíà. /2263ê/95/
- Óãíåòàåò ãèïîòàëàìî-ãèïîôèçàðíî-ãîíàäíóþ ñèñòåìó./7758/90/
4. Ñòèìóëÿöèÿ _êðàñíîãî êîñòíîãî ìîçãà .: ëåéêîöèòîç. /2263ê/95/
5. Óñèëåíèå ñåêðåöèè _êîëëàãåíàçû . ñèíîâèàëüíûìè êëåòêàìè.
/2292ê/
6. Àíîðåêñèÿ. /2263ê/95/
7. Ñòèìóëÿöèÿ _ãåïàòîöèòîâ . (ñèíòåçà ÁÎÔ). /2292ê/
8. Ïîäàâëåíèå àêòèâíîñòè ëèïîïðîòåèíëèïàçû (æèðîâàÿ òêàíü).
/2292ê/
9 2. Àêòèâàöèÿ êëåòîê
- ìàêðîôàãîâ (óñèëåíèå ïðîäóêöèè ÔÍÎ, ÈË-6, ÔÀÒ, ËÒ, ÒÕ À2,
Pg, àóòîêðèííàÿ àêòèâàöèÿ).
- íåéòðîôèëîâ (óñèëåíèå àêêóìóëÿöèè è àêòèâàöèè)
- Ñòèìóëÿöèÿ Ò- è Â-êëåòîê. /2460ê/
-- Òõ (ñòèìóëÿöèÿ ñèíòåçà ëèìôîêèíîâ, ñåêðåöèè ÈË-2, ýêñ-
ïðåññèè ðåöåïòîðîâ äëÿ ÈË-2),
- ñòèìóëèðóåò àêòèâíîñòü Òê /2348ê/,
- ÅÊÊ (ÈË-1 èíäóöèðóåò åñòåñòâåííóþ êèëëåðíóþ àêòèâíîñòü
/2348ê/)
- ïîëèìîðôîíóêëåàðîâ (ñòèìóëèðóåò àäãåçèþ íåéòðîôèëîâ
/2348ê/),
- ÝÊ. Èíäóöèðóåò ïðîêîàãóëÿíòíûå ñâîéñòâà ãðàíóëîöèòîâ è ÝÊ.
Ïîâûøàåò ñèíòåç òêàíåâîãî ôàêòîðà, èíãèáèòîðà ïëàçìèíîãåíà
ýíäîòåëèàëüíûìè êëåòêàìè, ñòèìóëÿöèÿ ñèíòåçà ïðîñòàãëàíäè-
íîâ (ïðîñòàöèêëèíà-?), ÔÀÒ.
- õîíäðîöèòîâ,
- îñòåîêëàñòîâ,
- ôèáðîáëàñòîâ (ðåãóëÿöèÿ ïðîòèôåðàöèè è ñåêðåòîðíîé àêòèâ-
íîñòè) /2292ê/, àêòèâèðóåò ïðîëèôåðàöèþ êëåòîê ñîåäèíè-
òåëüíîé òêàíè /2348ê/,
- òèðåîöèòîâ,
- áåòà-êëåòîê,
- ãåïàòîöèòîâ. /2263ê/95/
ßâëÿåòñÿ _õåìîàòòðàêòàíòîì . äëÿ ìîíîöèòîâ, íåéòðîôèëîâ, Ò-
è Â-ëèìôîöèòîâ, âûçûâàåò äåãðàíóëÿöèþ íåéòðîôèëîâ ñ âûñâî-
áîæäåíèåì ìèåëîïåðîêñèäàçû.
Óñèëåíèå _àäãåçèè . (ïîâûøåíèå ýêñïðåññèè àäãåçèâíûõ ìîëå-
êóë) ÝÊ, íåéòðîôèëîâ, ýîçèíîôèëîâ, áàçîôèëîâ, ìîíîöèòîâ è
(â ìåíüøåé ñòåïåíè) ëèìôîöèòîâ. /2292ê/
10. Âëèÿåò íà ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó _Â-ëèìôîöèòîâ . (ñòà-
áèëèçèðóþùåå âëèÿíèå íà ïðîëèôåðàöèþ Â-ëèìôîöèòîâ è îáðàçî-
âàíèå ÀÒ). /2292ê/
1ÈË-1, ÔÍÎ-àëüôà è ÈË-6, íå ÿâëÿÿñü ñàìîñòîÿòåëüíûìè ðîñòîâû-
1ìè ôàêòîðàìè äëÿ òèìîöèòîâ è çðåëûõ Ò-êëåòîê, ñïîñîáíû óñè-
1ëèòü ðîñòîâîå äåéñòâèå ÈË-2, èë-4 è ÈË-7, ò.å. ñëóæàò èõ êî-
1ôàêòîðàìè. /2317ê/97/ 0 - ÏÎÂÒÎÐ
11. Ñòèìóëÿöèÿ ïðîëèôåðàöèè ÑÊÊ êîñòíîãî ìîçãà, ãëèàëüíûõ êëå-
òîê, Â-ëèìôîöèòîâ, Ò-ëèìôîöèòîâ, êåðàòèíîöèòîâ6 ôèáðîáëàñ-
òîâ, ýíäîòåëèîöèòîâ. /2460ê/95/
11. Èíäóöèðóåò _ñèíòåç . _ÁÎÔ, .öèòîêèíîâ _ .(ÈË-1,2, _ÈË-3, .4,6,8,9, _ ÈÔ
/?/ _, . _ÔÍÎ, ÊÑÔ . (Ã-, Ì-, ÃÌ-ÊÑÔ) _, ÔÀÒ . /?/, Å-ñåëåêòèíà,
ICAM-1 INCAM, RANTES, Pg E 42 0. /2460ê, .../ Ñèíåðãåòè÷åñêîå
äåéñòâèå ñ ÔÍÎ; ïîâûøåíèå ÷óâñòâèòåëüíîñòè êëåòîê ê ÔÍÎ.
/2292ê/ ÈË-1 èíäóöèðóåò ñèíòåç ýïèäåðìàëüíîãî ÔÐ (ôàêòîðà
ðîñòà), ÔÐ ôèáðîáëàñòîâ. /2348ê/ Èíäóêöèÿ ñèíòåçà àäãåçèâ-
íûõ ôàêòîðîâ ïëàçìèíîãåííîãî àêòèâàòîðà. /2460ê/ Ìîäóëÿöèÿ
ýêñïðåññèè ðåöåïòîðîà äëÿ ÈË-1, ÈË-2, Ã-ÊÑÔ, ÃÌ-ÊÑÔ, ÔÍÎ.
/2460ê/
12. Ñïîñîáñòâóåò àêòèâàöèè _ôîñôîëèïàçû À2 . (ñèíòåçó Ðg E2, Pg I
- ? ÝÊ, ÔÀÒ). Èíäóêöèÿ ñèíòåçà ÑÎÄ ìîíîöèòàìè. /2460ê/
13. Ñòèìóëèðóåò ïðîêîàãóëÿíòíóþ àêòèâíîñòü (âûáðîñ òðîìáîïëàñ-
òèíà ÝÊ-ìè è ìîíîöèòàìè/ìàêðîôàãàìè). /2460ê/
13. Ðàäèîïðîòåêöèÿ. /2263ê/95/
14. Èñïîëüçóåòñÿ äëÿ ëå÷åíèÿ îíêîëîãè÷åñêèõ çàáîëåâàíèé. Ðàñò-
âîðèìûå ðåöåïòîðû äëÿ ÈË-1 è ÈË-1-ðåöåïòîðíûé àíòàãîíèñò
èñïîëüçóþòñÿ äëÿ ëå÷åíèÿ èíôåêöèîííûõ è àóòîèììóííûõ çàáî-
ëåâàíèé. /2356ê/
_Àíòàãîíèñòû . ÈË-1:
- ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-1,
- ÈË-1-ðåöåïòîðíûé àíòåãîíèñò. /2356ê/
ÐÀÈË (ðåöåïòîðíûé àíòàãîíèñò ÈË-1) áëîêèðóåò ñèíòåç öèòîêè-
íîâ ÈË-1-àëüôà,áåòà, ÈË-8, ÔÍÎ-àëüôà. /2460ê/
1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé
1öèòîêèíîâ /2317ê/97/
1────────────┬───────────────────┬──────────────────────────────
1Ñèíäðîìû │Öèòîêèíû,âûçûâàþùèå│ Ïðîÿâëåíèÿ
1│äàííûé ñèíäðîì │
1────────────┼───────────────────┼──────────────────────────────
1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,
1íûé │ 3ÈË-1 1,2,3; │àäèíîìèÿ, óòîìëÿåìîñòü,
1ñèíäðîì │ÃÌ-ÊÑÔ, Ã-ÊÑÔ │ìûøå÷íûå áîëè. /2317ê/97/
1│ │
1Ñèíäðîì, │ÔÍÎ-àëüôà, │Ïàäåíèå ÀÄ, àöèäîç,
1ïîäîáíûé │ 3ÈË-1 1,2,6 │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,
1ñåïòè÷åñêîìó│ │êðîâîèçëèÿíèÿ,
1øîêó │ │ëåéêîïåíèÿ,
1│ │ëèõîðàäêà áåç áàêòåðèåìèè.
1│ │/2317ê/97/
1────────────┴───────────────────┴───────────────────────────────
.
ÈË-2 15,5 Ò-ëèìôîöèòû,Ò- è Â-ôàêòîð ðîñòà
LGL Àêòèâàöèÿ Ò-êëåòîê
Ýîçèíîôèëû è ÅÊÊ
/2229ê/ Ïðåïàðàò - "ðîíäîëåéêèí" /?/
Ýôôåêòû:
1. Ôàêòîð ðîñòà äëÿ Ò-õåëïåðîâ è Ò-ñóïðåññîðîâ, àêòèâèðîâàííûõ
ÀÃ è ÈË-1, Ò-êèëëåðîâ.
2. Ñòèìóëèðóåò ïðîëèôåðàöèþ, äèôôåðåíöèðîâêó è ôóíêöèîíàëüíóþ
àêòèâíîñòü Âëèìôîöèòîâ.
3. Óñèëèâàåò ïðîäóêöèþ ÅÊÊ. Ñòèìóëèðóåò ïðîäóêöèþ 5 7b 0-ÔÍÎ.
4. Ñòèìóëèðóåò àíòèìèêðîáíóþ àêòèâíîñòü ìàêðîôàãîâ (çà ñ÷åò
ïðîäóêöèè ðàäèêàëüíûõ ôîðì êèñëîðîäà, 7 g 0-ÈÔ, ÔÍÎ è äð.)
5. Àêòèâèðóåò ÝÊ. Âûçûâàåò ëèçèñ ÝÊ àêòèâèðîâàííûìè ëèìôîöèòà-
ìè --- ïîâûøåíèå ïðîíèöàåìîñòè ñîñóäèñòîé ñòåíêè --- ---
îòåê --- àêòèâàöèÿ ãåìîñòàçà --- èøåìè÷åñêèé íåêðîç êèøå÷-
íèêà (ïðîáîäåíèå ñèãìîâèäíîé êèøêè).
6. Ââåäåíèå ÈË-2 ïîëíîñòüþ îòìåíÿåò ðàçâèòèå ïåðâè÷íîãî ÈÎ,
ñíèæàåò âòîðè÷íûé ÈÎ, ïîâûøàåò ÷àñòîòó áàêòåðèàëüíûõ èíôåê-
öèîííûõ îñëîæíåíèé.
7. Èñïîëüçóåòñÿ â àäîïòèâíîé òåðàïèè ðàêà /2283ê/96/, èíôåêöè-
îííûõ çàáîëåâàíèé. /2356ê/ ÈË-2-àíòàãîíèñò, ÈË-2-ñâÿçûâàþ-
ùèé òîêñèí èñïîëüçóþòñÿ äëÿ ëå÷åíèÿ àóòîèììóííûõ çàáîëåâà-
íèé; ÌÀÒ ïðîòèâ ÈË-2 ïðèìåíÿþòñÿ ïîñëå òðàíñïëàíòàöèè îðãà-
íîâ; ÈË-2-ñâÿçûâþùèé òîêñèí àïðîáèðóåòñÿ äëÿ ëå÷åíèÿ èíôåê-
öèîííûõ çàáîëåâàíèé. /2356ê/
8. Óñèëèâàåò òîêñè÷íîñòü ìîíîöèòîâ ïðîòèâ èíôåêöèîííûõ àãåíòîâ
è îïóõîëåâûõ êëåòîê, ïðîäóêöèþ ñâîáîäíûõ ôîðì êèñëîðîäà,
èíäóêöèþ ÈË-2-ðåöåïòîðà ãàììà-ñóáúåäèíèöû, ñèíòåç öèòîêèíîâ
ÈË-1, ÈË-6, ÔÍÎ-àëüôà. /2460ê/95/
_Àíòàãîíèñòû . ÈË-2:
- ÌÀÒ ïðîòèâ ÈË-2,
- ÈË-2-ñâÿçûâàþùèé òîêñèí,
- ÈË-2-àíòàãîíèñò. /2356ê/98/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-2 Ïîâûøåíèå óðîâíåé Ig G1, Ig E Ãåìîëèòè÷åñêàÿ
Ëå÷åíèå èíôåêöèîííûõ çàáîåëâàíèé. 1àíåìèÿ, õðîíè-
/2356ê/ 1÷åñêèé ýíòåðî-
1êîëèò
1Áåòà-öåïü Ïîâûøåíèå óðîâíåé Ig G1, Ig E Ãåìîëèòè÷åñêàÿ
1ÈË-2R àíåìèÿ
1Ãàììà-öåïü Íàðóøåíèå ðàçâèòèÿ Ò- è Â-êëåòîê,
1ÈË-2R îòñóòñòâèå NK- è 6ïd 4+ 1-Ò-êëåòîê
───────────────────────────────────────────────────────────────
1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé
1öèòîêèíîâ /2317ê/97/
1────────────┬───────────────────┬──────────────────────────────
1Ñèíäðîìû │Öèòîêèíû,âûçûâàþùèå│ Ïðîÿâëåíèÿ
1│äàííûé ñèíäðîì │
1────────────┼───────────────────┼──────────────────────────────
1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,
1íûé │ 3ÈË- 11, 32 1,3; │àäèíîìèÿ, óòîìëÿåìîñòü,
1ñèíäðîì │ÃÌ-ÊÑÔ, Ã-ÊÑÔ │ìûøå÷íûå áîëè. /2317ê/97/
1│ │
1Ñèíäðîì, │ÔÍÎ-àëüôà, │Ïàäåíèå ÀÄ, àöèäîç,
1ïîäîáíûé │ 3ÈË- 11, 32 1,6 │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,
1ñåïòè÷åñêîìó│ │êðîâîèçëèÿíèÿ,
1øîêó │ │ëåéêîïåíèÿ,
1│ │ëèõîðàäêà áåç áàêòåðèåìèè.
1│ │/2317ê/97/
1│ │
1Ñèíäðîì │ÔÍÎ-àëüôà, │Íàñìîðê,
1ïðîòåêàíèÿ │ 3ÈË-2 1, │ãèïîòåíçèÿ,
1êàïèëëÿðîâ │ÃÌ-ÊÑÔ, │äèàðåÿ,
1│ÌÀÒ ê ÑD3 │âîäÿíêà,îòåêè (îòåê ëåãêîãî),
1│ │æàæäà. /2317ê/97/
1────────────┴───────────────────┴───────────────────────────────
.
ÈË-3 28 Ò-ëèìôîöèòû Ãåìàòîïîýòè÷åñêèé ôàêòîð ðîñòà.
15-18 ìàêðîôàãè (=Ìóëüòè-ÊÑÔ - äëÿ ðàçíûõ êëåòî÷íûõ ëèíèé)
Ñòèìóëÿöèÿ ðîñòà è äèôôåðåíöèðîâêè ðàííèõ
ïðåäøåñòâåííèêîâ ìèåëîèäíûõ êëåòîê
Ýôôåêòû:
1. _Ïîëèïîýòèí .. /2263ê/95/ Ñòèìóëÿöèÿ ïðîëèôåðàöèè ÑÊÊ è ðàííèõ
ïðåäøåñòâåííèêîâ Ò- è Â-êëåòîê, êåðàòèíîöèòîâ, ôèáðîáëàñòîâ,
ýíäîòåëèîöèòîâ. /2460ê/95/ (Ýôôåêòèâíîñòü ÈË-3 ñîñòàâëÿåò 2%
àêòèâíîñòè ÊÑÔ). Óâåëè÷èâàåò ýêñïðåññèþ ðåöåïòîðîâ äëÿ ÊÑÔ.
Ìîæåò èñïîëüçîâàòüñÿ ëäÿ ëå÷åíèÿ öèòîïåíèé, ëåéêîçîâ.
/2300ê/ ßâëÿåòñÿ ôàêòîðîì ðîñòà äëÿ Â-êëåòîê. /2460ê/
 äîçàõ 30-500 ìêã/ì 52 0 /?/ óâåëè÷èâàåò ÷èñëî ëåéêîöèòîâ â 2
ðàçà, áàçîôèëîâ - â 8 ðàç, ýîçèíîôèëîâ - â 23. /2300ê/96/
2. Ó÷àñòâóåò â _äèôôåðåíöèðîâêå ÒÊ .. /2460ê/
Ñòèìóëèðóåò ôóíêöèîíàëüíóþ àêòèâíîñòü _áàçîôèëîâ . (ïîâûøàåò
÷óâñòâèòåëüîñòü ê Ñ3à, ðåàêöèþ äåãðàíóëÿöèè) è òó÷íûõ êëå-
òîê. /2263ê,2300ê/ Âûçûâàåò ïðÿìîå îñâîáîæäåíèå ãèñòàìèíà èç
áàçîôèëîâ. /2300ê,2263ê/ Óñèëèâàåò àëëåðãèþ.
3. Óñèëèâàåò _ïðîäóêöèþ öèòîêèíîâ .
- ÈË-8. /2460ê/
- Èíäóöèðóåò ñèíòåç ÈË-1, ÔÍÎ-àëüôà. /2460ê/95/
- àíòèãåíîâ HLA II ìàêðîôàãàìè.
- ÈË-2R-ãàììà-ñóáúåäèíèöû. /2460ê/
4. Àêòèâèðóåò ôàãîöèòîç è ïðîäóêöèþ ñâîáîäíûõ ðàäèêàëîâ. /2460ê/
5. Óñèëèâàåò àäãåçèþ ê ýíäîòåëèþ. /2460ê/
ÈË-3 èñïîëüçóåòñÿ äëÿ ëå÷åíèÿ îïóõîëåâûõ çàáîëåâàíèé è â
òðàíñïëàíòîëîãèè. /2356ê/
Ïðè íåäîñòàòî÷íîñòè _ÈË-3 è ÃÌ-ÊÑÔ . ïîðàæàþòñÿ ëåãêèå
/2317ê/97/;
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
ÈË-3 Èñïîëüçóåòñÿ ïîñëå òðàíñïëàíòàöèè
êðàñíîãî êîñòíîãî ìîçãà. /2356ê/
1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé
1öèòîêèíîâ /2317ê/97/
1────────────┬───────────────────┬──────────────────────────────
1Ñèíäðîìû │Öèòîêèíû,âûçûâàþùèå│ Ïðîÿâëåíèÿ
1│äàííûé ñèíäðîì │
1────────────┼───────────────────┼──────────────────────────────
1Ãðèïïîïîäîá-│ÈÔ-àëüôà,áåòà,ãàììà│Íåäîìîãàíèå, ïîòåðÿ àïïåòèòà,
1íûé │ 3ÈË 1-1,2, 33 1; │àäèíîìèÿ, óòîìëÿåìîñòü,
1ñèíäðîì │ÃÌ-ÊÑÔ, Ã-ÊÑÔ │ìûøå÷íûå áîëè. /2317ê/97/
1────────────┴───────────────────┴───────────────────────────────
.
? (Òõ-2)
ÈË-4 20 Ò 4í 01 êëåòêè, Â-ôàêòîð ðîñòà (Â-êëåòî÷íî-ñòèìóëèðóþùèé
12-20 Â-ëèìôîöèòû ôàêòîð-1), _ñòèìóëÿöèÿ Ig E ðåàêöèé .. Ñòè-
ìóëÿöèÿ ïåðåêëþ÷åíèÿ Ig E è ðîñòà òó÷íûõ
êëåòîê.
Ñïîñîáñòâóåò äèôôåðåíöèðîâêå _Òõ0 â Òõ2 ..
Ýôôåêòû:
1. Óñèëèâàåò ðîñò Â-êëåòîê.
2. Èíäóêöèÿ íà Â-ëèìôîöèòàõ ïåðåêëþ÷åíèÿ ýêñïðåññèè ìåìáðàííîãî
Ig Ì _íà ìåìáðàííûé Ig E è Ig G4 .. /2263ê/ Ïîñëå óäàëåíèÿ ãåíà
ÈË-4 ðåçêî ñíèàåòñÿ âûðàáîòêà Ig E. /2317ê/97/
Îòñóòñòâóåò äóáëèðîâàíèå _ÈË-4 .. Ïîñëå óäàëåíèÿ ãåíà ÈË-4 ðåç-
êî ñíèàåòñÿ âûðàáîòêà Ig E. /2317ê/97/
- _Ôàêòîð ðîñòà òó÷íûõ êëåòîê .. /2263ê/.
3. Ñïîñîáñòâóåò äèôôåðåíöèðîâêå _Òõ0 â Òõ2 .. /2300ê/
4. _Óãíåòàåò ïðîäóêöèþ
- _öèòîêèíîâ . ÈË-1, ÈË-6, ÈË-8,
- ÔÍÎ,
- Pg E 42
- ýêñïðåññèþ äèôôåðåíöèðîâî÷íûõ ìàðêåðîâ CD 14, CD 32, CD
64. /2300ê/
- òêàíåâîãî ôàêòîðà. /2460ê/
_Ñòèìóëÿòîð îáðàçîâàíèÿ .
- àêòèâàòîðà ïëàçìèíîãåíà ìîíîöèòàìè.
- ÐÀÈË (ðàñòâîðèìîãî àíòàãîíèñòà ÈË-1),
- Ã-ÊÑÔ, ÃÌ-ÊÑÔ
- ýêñïðåññèþ ãåíîâ ÃÊÃ I êëàññà,
- àäãåçèâíûõ ìîëåêóë CD11/CD18 è ìàðêåðîâ CD23. /2460ê/
4- Àíòàãîíèñò ÈË-2 Â-ëèìôîöèòîâ. Êîñòèìóëÿòîð ÈË-2 Ò-ëèìôîöèòîâ.
5. Ôàêòîð ðîñòà è ðåãóëÿòîð _àêòèâíîñòè ÝÊ ..
7. Âûçûâàåò _ðåçîðáöèþ êîñòåé ., èíäóöèðîâàííóþ ïàðàòèðåîèäíûì
ãîðìîíîì.
8. Èíãèáèðóåò öèòîòîêñè÷íîñòü. /2460ê/
_Àíòàãîíèñòû . ÈË-4:
- ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-4,
- ÈË-4-ñâÿçûâàþùèé ïðîòåèí. /2356ê/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-4 Èñ÷åçíîâåíèå Ig E, ñíèæåíèå óðîâíÿ
1Ig G1, äåôèöèò Th2
1───────────────────────────────────────────────────────────────
.
ÈË-5 50-60 Ò 4í 01 êëåòêè Ñòèìóëÿöèÿ Â-êëåòîê è ýîçèíîôèëîâ.
/?-Òõ2-?/ Ñòèìóëÿöèÿ ïåðåêëþ÷åíèÿ íà Ig A è ýîçè-
íîôèëèÿ.
Ýôôåêòû:
1. Ñòèìóëèðóåò ïðîëèôåðàöèþ, äèôôåðåíöèðîâêó è ôóíêöèîíàëüíóþ
àêòèâíîñòü _ýîçèíîôèëîâ .. Ïðè èíàêòèâàöèè ãåíà ÈË-5 ðàçâèâàåò-
ñÿ ýîçèíîôèëîïåíèÿ. /2317ê/97/
2. Ôàêòîð _äèôôåðåíöèðîâêè . òèìîöèòîâ â öèòîòîêñè÷åñêèå Ò-ëèìôî-
öèòû è Â-ëèìôîöèîâ â ÀÎÊ (èíäóöèðóåò ñåêðåöèþ Ig G, Ig M, Ig
E, Ig A). /2300ê/
3. Ïðè èíàêòèâàöèè ãåíà _ÈË-5 . ðàçâèâàåòñÿ ýîçèíîôèëîïåíèÿ.
/2317ê/97/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-5 Îòñóòñòâèå ýîçèíîôèëîâ, äåôèöèò Th2
1───────────────────────────────────────────────────────────────
.
?
ÈË-6 26 Ò 4í 01 êëåòêè, Îáëàäàåò _ïðîòèâîâîñïàëèòåëüíûì ñâîéñòâîì ..
ìîí/ìàêð., /2460ê/95/
ÝÊ, ôèáðî- Ôàêòîð ðîñòà /?/ ãèáðèäîìû.
áëàñòû, Óñèëèâàåò êîíå÷íóþ äèôôåðåíöèðîâêó Â-ëèì-
êëåòêè Êóï- ôîöèòîâ ( _Â-êëåòî÷íî-ñòèìóëèðóþùèé ôàêòîð .).
ôåðà (ËÏÑ) /2263ê/
/7631/92/,
Â-ëèìôîöèòû, 2 Èíäóêòîðû 0: - ìèòîãåíû Ò-êëåòîê,
êåðàòîöèòû, - âèðóñ Ýïøòåéíà-Áàðð,
îñòðîâêè - S. aureus Cowan I,
ïîäæåëóä. - ÈË-4 äëÿ Â-ëèìôîöèòîâ,
æåëåçû, - ËÏÑ äëÿ ôèáðîáëàñòîâ,
çëîêà÷åñò. - áàêòåðèè è âèðóñû äëÿ
êëåòêè ìàêðîôàãîâ./2317ê/97/
/2263ê/
Ýôôåêòû:
1. Àêòèâèðóåò ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó _Ò- è Â-êëåòîê ..
- Ôàêòîð ðîñòà Â-êëåòîê è ïîëèêëîíàëüíàÿ ïðîäóêöèÿ Ig (Ì, G,
A). ÈË-6 ÿâëÿåòñÿ ãëàâíûì èíäóêòîðîì êîíåíîé äèôôåðåíöèðîâêè
Â-êëåòîê. /2348ê/ Èçáûòî÷íàÿ ïðîäóêöèÿ ÈË-6 ìîæåò ïðèâåñòè ê
çëîêà÷åñòâåííîìó ïåðåðîæäåíèþ Â-êëåòîê. Ðåöåïòîðîâ äëÿ ÈË-6
ìíîãî íà ìèåëîìíûõ êëåòêàõ.
- 1ÈË-1, ÔÍÎ-àëüôà è ÈË-6, íå ÿâëÿÿñü ñàìîñòîÿòåëüíûìè ðîñòî-
1âûìè ôàêòîðàìè äëÿ òèìîöèòîâ è çðåëûõ Ò-êëåòîê, ñïîñîáíû
1óñèëèòü ðîñòîâîå äåéñòâèå ÈË-2, èë-4 è ÈË-7, ò.å. ñëóæàò èõ
1êîôàêòîðàìè. /2317ê/97/ 0 - ÏÎÂÒÎÐ Â êàêîé-òî ñòåïåíè ÈË-6 ìî-
æåò ïîäìåíèòü ôóíêöèþ ìîíîöèòîâ/ìàêðîôàãîâ â êà÷åñòâå äîïîë-
íèòåëüíîãî ñèãíàëà â ïîääåðæàíèè Ò-êëåòî÷íîé àêòèâàöèè.
/2348ê/
2. _Ïîäàâëÿåò âûðàáîòêó
- ÈË-1 è ÔÍÎ-àëüôà. ßâëÿåòñÿ òèïè÷íûì ïðîòèâîâîñïàëèòåëüíûì
öèòîêèíîì. Òîðìîæåíèå ïðîäóêöèè _ÔÍÎ . ïðè èíòðàòðàõåàëüíîé
èíñòèëëÿöèè ËÏÑ. /2292ê/
5Ñèíåðãèñò ÈË-1, ÔÍÎ. 0 5/8Ê1213-93-Èì-ÿ/ - ?
Ïðè äåôèöèòå _ÈË-6 è Ì-ÊÑÔ . ðàçâèâàåòñÿ ïîðàæåíèå êîñòåé
/2317ê/97/,
4. _Èíäóöèðóåò ñèíòåç
- ðåöåïòîðíîãî àíòàãîíèñòà ÈË-1 è ðàñòâîðèìîãî ðåöåïòîðà äëÿ
ÔÍÎ./2460ê/95/
- Èíäóöèðóåò ïðîäóêöèþ ÈË-2 è åãî ðåöåïòîðà. --- Óñèëèâàåò
àêòèâíîñòü ÅÊÊ. /2460ê/95/
- Óñèëèâàåò ýêñïðåññèþ äèôôåðåíöèðîâî÷íûõ ìàðêåðîâ. /2460ê/
- ÀÃ HLA I êëàññà& /2460ê/
- óñèëèâàåò ïðîäóêöèþ íåñïåöèôè÷åñêèõ ýñòåðàç, ëèçîöèìà.
/2460ê/
- ðåöåïòîðà äëÿ Ì-ÊÑÔ /2460ê/
- ïðîäóêöèþ ÐÀÈË /2460ê/
- ðåöåïòîðà äëÿ ÔÍÎ /2460ê/
- Èíäóöèðóåò ñèíòåç ÁÎÔ, êîðòèêîòðîïèíà è ÔÐÍ. /2460ê/ _Ãåïà-
_òîöèò .-ñòèìóëèðóþùèé ôàêòîð. Èíäóöèðóåò ñèíòåç ÁÎÔ ãåïàòî-
öèòàìè ïå÷åíè ïðè âîçäåéñòâèè ÈË-1. Âûçûâàåò òðàíñêðèïöèþ
ìÐÍÊ Ñ-ÐÁ. /2348ê/
ßâëÿåòñÿ ìîùíûì ñòèìóëîì òàêîé ñèñòåìíîé ðåàêöèè, êàê îñò-
ðîôàçíûé îòâåò íà òêàíåâîå ïîâðåæäåíèå (òðàâìà èëè èíôåê-
öèÿ). /2348ê/ _Óðîâåíü ïîâûøàåòñÿ ïðè âîñïàëåíèè .. /8Ê1212-
93-Èì-ÿ/ Ìîáèëèçàöèÿ _íåéòðîôèëîâ â î÷àãè âîñïàëåíèÿ .. /2292ê/
Óñèëèâàåò ôàãîöèòîç. /2460ê/
Èíäóöèðóåò _àïîïòîç íåéòðîôèëîâ .. /2460ê/95/
Ó ìûøåé ñ äåôåêòíûì ãåíîì ÈË-6 íàðóøåíà ïðîäóêöèÿ îñòðî-
ôàçíûõ áåëêîâ, ñíèæåí òèòð ñïåöèôè÷åñêèõ èììóíîãëîáóëèíîâ
G è Òê ïðè èíôåöèè, âûçâàííîé âèðóñîì âåçèêóëÿðíîãî ñòîìà-
òèòà, ïîâûøåíà ÷óâñòâèòåëüíîñòü ê ëèñòåðèÿì (äåôåêò Òê).
/2460ê/
- Óñèëåíèå ñåêðåöèè _ÀÊÒÃ .. /2292ê/
4. _Àêòèâàöèÿ ÝÊ . (ñèíòåç ôàêòîðà ðîñòà òðîìáîöèòîâ), ïîâûøåíèå
ïðîíèöàåìîñòè. /2292ê/
7. - _Ñèíåðãèñò ÈË-3 . (ðåãóëèðóåò ãåìîïîýç òðîìáîöèòîâ, àêòèâèðó-
åò ïåðåõîä ìåãàêàðèîöèòîâ â òðîìáîöèòû). /8Ê1213-93-Èì-ÿ/
- Àêòèâèðóåò ïðîëèôåðàöèþ _ñòâîëîâûõ êëåòîê . è èíäóöèðóåò ñèí-
òåç Ã- è ÃÌ-ÊÑÔ. /2460ê/95/
5- Èíãèáèðóåò ïðîëèôåðàöèþ /2460ê/ 0- ?
- Èíäóöèðóåò ñîçðåâàíèå ìåãàêàðèîöèòîâ è îñòåîáëàñòîâ. /2460ê/
- Ñòèìóëèðóåò ðîñò ìåçàíãèàëüíûõ êëåòîê, êåðàòèíîöèòîâ è
äèôôåðåíöèðîâêó íåéðîíîâ, êëåòîê-ïðåäøåñòâåííèêîâ ãðàíóëî-
öèòîâ è ìàêðîôàãîâ. /2460ê/95/
13. Èíãèáèðóåò ïðîëèôåðàöèþ _ìàêðîôàãîâ . è óñèëèâàåò èõ äèôôåðåí-
öèðîâêó. /2460ê/95/
Èçáûòî÷íàÿ ïðîäóêöèÿ ÈË-6 ìîæåò ïðèâåñòè ê ðàçâèòèþ àóòîèì-
ìóííûõ çàáîëåâàíèé.
_Àíòàãîíèñòû . ÈË-6:
- ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-7,
- ÈË-6-ñâÿçûâàþùèé òîêñèí. /2356ê/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-6 Ñíèæåíèå óðîâíÿ Ig A. Íàðóøåíèå âûðà- Ïîâðåäåíèå êîñ-
1áîòêè îñòðîôàçíûõ áåëêîâ. Ñíèæåíèå òåé
1îáðàçîâàíèÿ Ig G-îòâåòà, àêòèâíîñòè
1öèòîòîêñè÷íûõ Ò-ëèìôîöèòîâ ïðè âèðóñ-
1íûõ èíôåêöèÿõ.
Èñïîëüçóåòñÿ ïîñëå òðàíñïëàíòàöèè
êðàñíîãî êîñòíîãî ìîçãà. /2356ê/
1───────────────────────────────────────────────────────────────
1Ñèíäðîìû, âûçûâàåìûå ïåðäîçèðîâêîé
1öèòîêèíîâ /2317ê/97/
1────────────┬───────────────────┬──────────────────────────────
1Ñèíäðîìû │Öèòîêèíû,âûçûâàþùèå│ Ïðîÿâëåíèÿ
1│äàííûé ñèíäðîì │
1────────────┼───────────────────┼──────────────────────────────
1Ñèíäðîì, │ÔÍÎ-àëüôà, │Ïàäåíèå ÀÄ, àöèäîç,
1ïîäîáíûé │ 3ÈË 1-1,2, 36 1 │âíóòðèñîñóäèñòàÿ êîàãóëÿöèÿ,
1ñåïòè÷åñêîìó│ │êðîâîèçëèÿíèÿ,
1øîêó │ │ëåéêîïåíèÿ,
1│ │ëèõîðàäêà áåç áàêòåðèåìèè.
1│ │/2317ê/97/
1────────────┴───────────────────┴───────────────────────────────
.
ÈË-7 25 Còðîìàëüíûå _Ëèìôîïîýòèí . äëÿ ïðî-Â-êëåòîê,
êëåòêè êð. ëèìôîöèòàðíûé ôàêòîð ðîñòà - óñèëèâàåò
êîñòíîãî ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó Ò-ëèôîöèòîâ
ìîçãà è â Òõ è Òñ.
òèìóñà
çàðîäûøà,
Ò-ëèìôîöèòû
Ýôôåêòû:
1. Ðåãóëèðóåò ïðîëèôåðàöèþ è äèôôåðåíöèðîâêó Ò- è Â-ëèìôîöèòîâ
(èíäóöèðóåò ýêñïðåññèþ ðåöåïòîðîâ ê ÈË-2, òðàíñôåððèíó).
Îòêëþ÷åíèå ãåíà _ÈË-7 . ïðèâîäèò ê íàðóøåíèþ âñåõ âåòâåé ëèìôî-
ïîýçà. /2317ê/97/
2. Ïîâûøàåò öèòîòîêñè÷íîñòü âî êëåòîê CTL è NK.
3. Àêòèâèðóåò è ñòèìóëèðóåò ìîíîöèòû. /2300ê/
4. Óñèëèâàåò ïðîòèâîîïóõîëåâóþ àêòèâíîñòü. /2460ê/
.
ÈË-8 8,8 Ìîí./ìàêð., _Õåìîàòòðàêòàíò .û íåéòðîôèëîâ, Ò-ëèìôîöè-
│ ÝÊ, ëèìôî- òîâ, ìîíîöèòîâ. /2263ê/
6,5 öèòû,ôèáðî- Ðåãóëÿöèÿ õîìèíãà ëèìôîöèòîâ è èíôèëüò-
(àêò. áëàñòû,çëî- ðàöèè íåéòðîôèëîâ.
ôîðìà) êà÷åñòâåí-
íûå êëåòêè
Ñèíòåç ÈË-8 ñòèìóëèðóåòñÿ â ýíäîòåëèàëüíûõ êëåêòêàõ òðîìáè-
íîì. /2250ê/96/
Ýôôåêòû:
1. Ñòèìóëèðóåò
- õåìîòàêñèñ íåéòðîôèëîâ è Ò-ëèìôîöèòîâ /2300ê/
-- àêêóìóëÿöèÿ íåéòðîôèëîâ â î÷àã âîñïàëåíèÿ (ëîêàëüíîå
äåéñòâèå); ÈË-8 àêòèâèðóåò äâèãàòåëüíûé àïïàðàò êëåòîê,
íàïðàâëåíèå ìèãðàöèè, ýêñïðåññèþ ìîëåêóë àäãåçèè /2348ê/;
-- ïîäàâëåíèå ýìèãðàöèè íåéòðîôèëîâ ïðè âíóòðèâåííîì ââåäå-
íèè (ñèñòåìíûé ýôôåêò). /2292ê/
- àäãåçèþ íåéòðîôèëîâ,
- àêòèâèðóåò âûáðîñ íåéòðîôèëàìè ôåðìåíòîâ è àêòèâíûõ ôîðì
êèñëîðîäà. /2300ê,2348ê/
2. Ñòèìóëèðóåò äåãðàíóëÿöèþ áàçîôèëîâ (âûáðîñ ãèñòàìèíà è ëåé-
êîòðèåíà).
3. Èíäóöèðóåò ëîêîìîöèþ ÈË-2-àêòèâèðîâàííûõ åñòåñòâåííûõ êèëëå-
ðîâ.
4. Óñèëèâàåò
- ìîáèëèçàöèþ âíóòðèêëåòî÷íîãî êàëüöèÿ /2460ê/
- Àêòâèðóåò ïðîäóêöèþ ÔÀÒ. /2460ê/95/
- ýêñïðåññèþ I òèïà ðåöåïòîðà äëÿ êîìïëåìåíòà è
- ýêñïðåññèþ àäãåçèâíûõ ìîëåêóë CD11/CD18 ãðàíóëîöèòîâ.
/2460ê/95/
5. Ñòèìóëèðóåò õåìîòàêñèñ Ò-ëèìôîöèòîâ. /2460ê/95/
6. Ñòèìóëèðóåò ïðîëèôåðàöèþ êåðàòèíîöèòîâ. /2460ê/95/
7. Óñèëèâàåò àäãåçèâíîñòü ìîíîöèòîâ ê ÝÊ /2460ê/ Óñèëèâàåò àí-
ãèîãåíåç. /2460ê/95/
8. Àêòèâèðóåò _äåãðàíóëÿöèþ ., âûõîä ëèçîñîìàëüíûõ ôåðìåíòîâ,
ðåñïèðàòîðíûé âçðûâ /2460ê/
_Àíòàãîíèñòû . ÈË-8:
- ðàñòâîðèìûå ðåöåïòîðû äëÿ ÈË-8. /2356ê/
_Ðåöåïòîðû íà
- íåéòðîôèëàõ,
- Ò-ëèìôîöèòàõ, à òàêæå íà
- òðàíñôîðìèðîâàííûõ êëåòêàõ ìèåëîìîíîöèòàðíîãî ïðîèñõîæäå-
íèÿ ÍL-60. /2326ê/97/
.
ÈË-9 ð40 Àêòèâèðî- Ò-êëåòî÷íûé ôàêòîð ðîñòà, ñòèìóëÿòîð
âàííûå Ò- ãåìàòîïîýçà.
ëèìôîöèòû
Ýôôåêòû:
1. Ðåãóëèðóåò ïðîëèôåðàöèþ òèìîöèòîâ. Âìåñòå ñ ÈË-2 ïîâûøàåò
ïðîëèôåðàöèþ ôåòàëüíûõ òèìîöèòîâ.
2. Ñòèìóëèðóåò ïðîëèôåðàöèþ ïðåäøåñòâåííèêîâ ýðèòðîèäíûõ êëå-
òîê.
.
ÈË-10 18 Â- è Ò 4í 02- Èììóíîñóïðåññèâíûé è ïðîòèâîâîñïàëèòåëü-
28-35 ëèìôîöèòû, íûé öèòîêèí. /7591/93/
òèìîöèòû, Óíèâåðñàëüíûé _èíãèáèòîð ñèíòåçà ìîíîêè .-
ÒÊ, ÌÍÔ _íîâ .)
Àêòèâàòîð Ò-êèëëåðîâ è òèìîöèòîâ.
Äåéñòâèå íà Ò-, Â-êëåòêè, ÒÊ, èíãèáèòîð
Ò 4í 01 (ñèíòåçà öèòîêèíîâ),
ÈË-10 ãîìîëîãè÷åí ñ EBV-áåëêàìè.
Ýôôåêòû:
1. _Èììóíîñóïðåññîð ., ïîäàâëÿþùèé ôóíêöèè ìîíîöèòîâ è ìàêðîôàãîâ.
Áëîêèðóåò äåéñòâèå ðàííèõ ïðîâîñïàëèòåëüíûõ ìåäèàòîðîâ ïðè
ñåïòè÷åñêîì øîêå (ËÏÑ, ÔÍÎ). Èíãèáèöèÿ ñèíòåçà öèòîêèíîâ
Ò-õåëïåðàìè è ìàêðîôàãàìè. /?/ Èíãèáèðóåò ïðîäóêöèþ ÈË-2.
Èíãèáèðóåò ïðåäñòàâëåíèå ÀÃ ìàêðîôàíàìè, ñíèæàÿ ýêñïðåññèþ
Àà II ÃÊÃ, ñíèæàåò ýêñïðåññèþ Ò-êëåòî÷íîãî àíòèãåííîãî ðå-
öåïòîðà, ðåöåïòîðà äëÿ ÈË-2. /2460ê/95/
2. Ï _ðîòèâîâîñïàëèòåëüíûé öèòîêèí .. /7591/93/
_Ïîäàâëÿåò îáðàçîâàíèå
- ÈË-1, ÈË-3, ÈË-6, ÈË-8, ÈË-12 /?/
- ÃÌ-ÊÑÔ, Ã-ÊÑÔ, Ì-ÊÑÔ
- ÔÍÎ /2460ê/95/, ÈË-10 óñèëèâàåò øåääèíã sTNF-R ñ ìîíîöèòîâ
êðîâè /2461ê/
- áëîêèðóåò ïðîäóêöèþ ÒÔÐ. /2461ê/
- ÈË-2 /?/.
- Ïîäàâëÿåò ýêñïðåññèþ àíòèãåíîâ II êëàññà. /2300ê/
- òêàíåâîãî ôàêòîðà /2460ê/
- ÈÔ-àëüôà,ãàììà (Òõ-ìè)
- ñóïåðîêñèäíûõ è íèòðîêñèäíûõ ðàäèêàëîâ àêòèâèðîâàííûìè ìî-
íîöèòàìè,
- ïîâåðõíîñòíûõ äèôôåðåíöèðîâî÷íûõ ìàðêåðîâ
- ïðîäóêöèþ HLA II è ÈË-1 ìàêðîôàãàìè.
_Àêòèâèðóåò ïðîäóêöèþ
- ÐÀÈË (ðåöåïòîðíîãî àíòàãîíèñòà ÈË-1). /2460ê/
2. Ôàêòîð äèôôåðåíöèðîâêè Ò-êèëëåðîâ. /?/ Èíãèáèðóåò öèòîòîê-
ñè÷íîñòü /2460ê/95/
3. Ïðîëèôåðàöèÿ çðåëûõ è íåçðåëûõ òèìîöèòîâ â ïðèñóòñòâèè ÈË-2
è ÈË-4;
- Ñíèæàåò ïðîëèôåðàöèþ Ò-ëèìôîöèòîâ, èíäóöèðîâàííóþ àí-
òè-CD-23-ÀÒ, ÈË-1, ÈË-6, ÔÍÎ. /2460ê/95/
4. Ñòèìóëÿöèÿ òó÷íûõ êëåòîê ïðè êîìáèíàöèè ñ ÈË-3 è/èëè ÈË-4;
5. Âìåøàòåëüñòâî (ïîìåõà-?) â ïðîöåññ ïðåçåíòàöèè ÀÃ.
6. Óñèëèâàåò ñèíòåç Ig M è Ig E.
7. 5Àëüôà-ÔÍÎ àêòèâèðóåò NO-ñèíòåòàçó, âûçûâàþùåé îáðàçîâàíèå
5NO-ðåàêòèâíûõ ìåòàáîëèòîâ. 0ÈË-10 èíãèáèðóåò NO-ñèíòåòàçó.
/2294ê/95/
8. Ïðåäîòâðàùàåò àïîïòîç _Â-ëèìôîöèòîâ .. Óñèëèâàåò àòèâàöèþ, ïðî-
ëèôåðàöèþ è äèôôåðåíöèðîâêó Â-ëèìôîöèòîâ, èíäóöèðîâàííóþ
ÈË-2 è àíòè-Ig M-àíòèòåëàìè. Óñèëèâàåò ïðîäóêöèþ Ig M è Ig
E. Óñèëèâàåò ýêñïðåññèþ ïîâåðõíîñòíûõ ÀÃ Â-ëèìôîöèòîâ è ÒÊ.
/2460ê/95/
9. Ïðåäîòâðàùàåò ðàçâèòèå äèàáåòà. /2460ê/95/
10.Èíãèáèðóåò êèëëèíã ïàðàçèòîâ ìàêðîôàãàìè, ÿâëÿåòñÿ ïåðìåñ-
ñèâíûì äëÿ ðîñòà ìèêðîáíûõ ïàòîãåíîâ è îïóõîëåâûõ êëåòîê.
/2460ê/95/
_Ïðè óäàëåíèè ÈË-10 ïîðàæàåòñÿ êèøå÷íèê. /2317ê/97/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-10 0Ïðîòèâîâîñïàëèòåëüíûé àãåíò 1 Àíåìèÿ, âîñïàëè-
1òåëüíûå çàáîëå-
1âàíèÿ êèøå÷íèêà
1───────────────────────────────────────────────────────────────
.
ÈË-11 23 Ñòðîìàëü- Êîôàêòîð _ãåìîïîýçà .;
íûå êëåòêè Â-êëåòî÷íûé ôàêòîð ðîñòà;
êîñòíîãî ðåãóëÿòîð çàäåðæêè êëåòî÷íîãî öèêëà;
ìîçãà ñòèìóëÿòîð ÅÊÊ; àêòèâàòîð Ò-êèëëåðîâ.
Ýôôåêòû:
1. Ñèíåðãèñò ÈË-6.
2. Ñòèìóëÿöèÿ ñèíòåçà Ig G â ïðèñóòñòâèè Ò-êëåòîê.
3. Ñòèìóëÿöèÿ ìåãàêàðèîöèòîâ.
4. Ïðîòèâîâîñïàëèòåëüíûé öèòîêèí. /2356ê/
.
ÈË-12 75 Ìàêðîôàãè, Ñòèìóëÿöèÿ ÅÊÊ, àêòèâàöèÿ Ò- _êèëëåðîâ
ð40-ð35 Â-ëèìôîöèòû, (óñèëèâàåò êëåòî÷íûé ÈÎ).
íåéòðîôèëû, Ñèíòåçèðóåòñÿ ÀÏÊ --- ïåðåêëþ÷åíèå Òõ0 íà
äåíäðèòíûå Òõ1.
êëåòêè
Ïðîäóöèðóåòñÿ â îñíîâíîì ìàêðîôàãàìè è â ìåíüøåé ñòåïåíè
äðóãèìè ÀÏÊ â îòâåò íà Àà áàêòåðèé è âíóòðèêëåòî÷íûõ ïàðàçèòîâ.
/2460ê/95/
Ýôôåêòû:
1. Ôàêòîð ðîñòà àêòèâèðîâàííûõ Ò-ëèìôîöèòîâ (CD4+ è CD8+), ÅÊÊ
(CD 56), óñèëèâàåò ýôôåêò ÈË-2. Ñòèìóëÿöèÿ öèòîòîêñè÷íîñòè
ÅÊÊ. Ôàêòîð ñîçðåâàíèÿ êèëëåðîâ (ÅÊÊ,Ò). Èíäóöèðóåò äèôôå-
ðåíöèðîâêó ÖÒË.
2. Ñòèìóëÿöèÿ Òõ1, òîðìîæåíèå ñèíòåçà Ig E, àêòèâèðîâàííóþ ÈË-4
è ãàììà-ÈÔ-îì. 4 Ñïîñîáñòâóåò ðàçâèòèþ Òõ êëàññà 1. /2460ê/95/
Ó÷àñòâóåò â ïðîëèôåðàöèè è äèôôåðåíöèðîâêå Ò-ëèìôîöèòîâ (ïå-
ðåâîäå Òõ0 â Òõ1). ÈË-12 ÿâëÿåòñÿ âûðàæåííûì èíãèáèòîðîì ïå-
ðåõîäà Òõ0 â Òõ2. /2460ê/
3. Ñòèìóëÿöèÿ ëèìôîöèòàðíîé àêòèâíîñòè
- Óñèëèâàåò ïðîëèôåðàöèþ ëèìôîöèòîââ îòâåò àí ìèòîãåíû
- Èíäóöèðóåò ïðîäóêöèþ ÈÔ-ãàììà Ò-ëèìôîöèòàìè
- Ñòèìóëèðóåò ëèìôîêèí-àêòèâèðîâàííûå êèëëåðû
- Ïîòåíöèðóåò äåéñòâèå ÈË-2 íà ïðîëèôåðàöèþ ëèìôîöèòîâ
- Àêòèâèðóåò ÅÊÊ. Èíäóöèðóåò ñèíòåç öèòîêèíîâ ÈÔ-ãàììà,
ÔÍÎ-àëüôà, ÔÍÎ-áåòà ÅÊÊ-ìè.
- Óñèëèâàåò äåéñòâèå âàêöèíû ïðîòèâ ëåéøìàíèîçà
4. Óñèëèâàåò ýêñïðåññèþ ïîâåðõíîñòíûõ ÀÃ, ìîëåêóë àäãåçèè è ðå-
öåïòîðîâ: CD56, CD2, ICAM-1, LFA-1, áåòà- è ãàììà-öåïè
ÈË-2-ðåöåïòîðà, 75 êÄ-ðåöåïòîð äëÿ ÔÍÎ.
5. Óâåëè÷èâàåò óðîâíü NO, ïðîäóêöèþ õåìîòàêñèíîâ. /2634ê/99/
6 4. Ñèíåðãèçì ñ ÈË-2 â îòíîøåíèè öèòîòîêñè÷íîñòè ëèìôû /?/ è ãå-
4íåðàöèè LAK (ïîäîáíûå Òê).
7. Ââåäåíèå ÈË-12 ìîæåò âûçâàòü èììóíîòîêñè÷åñêèé ýôôåêò, ñâÿ-
çàííûé ÷àñòè÷íî ñ ïðîäóêöèåé ïðîâîñïàëèòåëüíûõ öèòîêèíîâ (ãàì-
ìà-ÈÔ è äð.).
Ò.î., âàæíåéøåå ñâÿçóþùåå çâåíî ìåæäó ñïåöèôè÷åñêîé è íåñïå-
öèôè÷åñêàîé çàùèòîé.
Ñèíåðãèñòû - ÈË-8, ÈË-2;
Àíòàãîíèñò - ÈË-10. /2634ê/99/
1 óñëîâèÿõ áëîêàäû Òõ1 ïðîäóêòàìè Òõ2 âíóòðèêëåòî÷íûå ïàðà-
1çèòû, íàïðèìåð, Toxoplasma gondii, ìîãóò èíäóöèðîâàòü ñèíòåç
1ìàêðîôàãàìè åùå îäíîãî öèòîêèíà - ÈË-12, êîòîðûé ìîæåò çàïóñ-
1òèòü Ò-íåçàâèñèìûé ñèíòåç ÈÔ-ãàììà ÅÊÊ-ìè. ÈË-10 down-ðåãóëèðó-
1åò ïðîäóêöèþ ÈË-12, ìàêðîôàãàìè, íî è ÈË-12 ñî ñâîåé ñòîðîíû,
1èíãèáèðóÿ äèôôåðåíöèðîâêó Òõ2, ìîæåò áëîêèðîâàòü ñèíòåç ÈË-10.
1Òàêèì îáðàçîì, ÈË-10 è ÈË-12 îêàçûâàþò àíòàãîíèñòè÷åñêîå äåéñ-
1òâèå íà ýôôåêòèâíîñòü êëåòî÷íîé çàùèòû. Îò ïðåîáëàäàíèÿ òîãî
1èëè èíîãî èç ýòèõ öèòîêèíîâ ìîãóò çàâèñåòü èñõîä èíôåêöèè è ýô-
1ôåêòèâíîñòü ïðîòèâîîïóõîëåâîé çàùèòû. /2461ê/
4. Èíäóöèðóåò ïðîäóêöèþ ãàììà-ÈÔ Ò-ëèìôîöèòàìè. Óñèëèâàåò ïðî-
ëèôåðàöèþ ëèìôîöèòîâ â îòâåò íà ìèòîãåíû. Ïîòåíöèðóåò äåéñòâè-
åÈË-2. /2460ê/95/
- Óñèëèâàåò äåéñòâèå âàêöèíû ïðîòèâ ëåéøìàíèîçà. /2460ê/95/
1Ïîñëåäñòâèÿ óäàëåíèÿ ãåíîâ öèòîêèíîâ
1èëè èõ ðåöåïòîðîâ /2317ê/97/
1───────────────────────────────────────────────────────────────
1Öèòîêèí, │ Îæèäàåìûå ïîñëåäñòâèÿ │ Íåîæèäàííûå
1ðåöåïòîðû│ │ ïîñëåäñòâèÿ
1───────────────────────────────────────────────────────────────
1ÈË-12 Îñëàáëåíèå îáðàçîâàíèÿ Òh1
Ëå÷åíèå èíôåöèîííûõ çàáîëåâàíèé. /2356ê/
1───────────────────────────────────────────────────────────────
.
ÈË-13 9- Ò-ëèìôîöèòû _Ïðîòèâîâîñïàëèòåëüíûé àãåíò
17 (Òõ2)
Ýôôåêòû:
1. Ïðîòèâîâîñïàëèòåëüíûé àãåíò
_Ñòèìóëÿöèÿ ñèíòåçà
- ðåöåïòîðíîãî àíòàãîíèñòà ÈË-1 (ÐÀÈË);
_Ïîäàâëÿåò îáðàçîâàíèå . ïðîâîñïàëèòåëüíûõ öèòîêèíîâ. Ïî õàðàê-
òåðó âëèÿíèÿ î÷åíü áëèçîê ê ÈË-4. /2461ê/
- ÈË-1, ÈË-6,
- ÔÍÎ
5Èíäóêöèÿ ï-ÈÔ ïðîäóêöèè ÐÂ2, Ò- è ÅÊÊ ÈË-6, ÈË-1, ÔÍÎ. - ???
2. Ñòèìóëèðóåò ïðîëèôåðàöèþ _ñòâîëîâûõ êëåòîê ., äèôôåðåíöèðîâêó
ìîíîöèòîâ. /2300ê/
3. Õåìîàòòðàêòîð äëÿ ìîíîöèòîâ.
4. Èíãèáèðóåò ïðîòèâîïàðàçèòàðíóþ àêòèâíîñòü, òîêñè÷íîñòü, ìàê-
ðîôàã-ñâÿçàííóþ èììóíîñóïðåññèþ. /2460ê/
.
ÈË-15
Ýôôåêòû:
1. Àêòèâèðóåò ÅÊÊ, ïðîëèôåðàöèþ Ò-ëèìôîöèòîâ, èõ äèôôåðåíöèðîâ-
êó â Òê. /2460ê/ Èíèöèèðóåò îáðàçîâàíèå ëèìôîêèíàêòèâèðîâàí-
íûõ êèëëåðîâ. /2460ê/95/
───────────────────────────────────────────────────────────────
Ïðèìå÷àíèå: ÝÊ - ýíäîòåëèàëüíûå êëåòêè
ðýñ - ðåòèêóëîýíäîòåëèàëüíàÿ ñèñòåìà
ÔÍÎ - ôàêòîð íåêðîçà îïóõîëåé
ÈÔ - èíòåðôåðîí
ÅÊÊ - åñòåñòâåííûå êëåòêè-êèëëåðû
Pg - ïðîñòàãëàíäèíû
ÔÀÒ - ôàêòîð àêòèâàöèè òðîìáîöèòîâ
.
Oppenheimer-Marks N. Brezinschek RI. Mohamadzadeh M. Vita R. Lipsky
PE.
_Interleukin 15 . is produced by endothelial cells and increases the
transendothelial migration of T cells In vitro and in the SCID mouse-human
rheumatoid arthritis model In vivo.
Source
Journal of Clinical Investigation. 101(6):1261-72, 1998 Mar 15.
The capacity of endothelial cells (EC) to produce IL-15 and the capacity
of IL-15 to influence transendothelial migration of T cells was examined.
Human umbilical vein endothelial cells expressed both IL-15 mRNA and
protein. Moreover, endothelial-derived IL-15 enhanced transendothelial
migration of T cells as evidenced by the inhibition of this process by
blocking monoclonal antibodies to IL-15. IL-15 enhanced transendothelial
migration of T cells by activating the binding capacity of the integrin
adhesion molecule LFA-1 (CD11a/CD18) and also increased T cell motility.
In addition, IL-15 induced expression of the early activation molecule
CD69. The importance of IL-15 in regulating migration of T cells in vivo
was documented by its capacity to enhance accumulation of adoptively
transferred human T cells in rheumatoid arthritis synovial tissue
engrafted into immune deficient SCID mice. These results demonstrate that
EC produce IL-15 and imply that endothelial IL-15 plays a critical role in
stimulation of T cells to extravasate into inflammatory tissue.
Lantero S. Sacco O. Scala C. Rossi GA.
Stimulation of blood mononuclear cells of atopic children with the
relevant allergen induces the release of eosinophil chemotaxins such as
_IL-3, IL-5, and GM-CSF.
Journal of Asthma. 34(2):141-52, 1997.
Peripheral blood mononuclear cells (PBMC) from 10 atopic asthmatic
children (atopics), sensitized to Dermatophagoides pteronyssinus (Dp), and
from 5 nonatopic healthy children (controls) were stimulated with Dp
extract or with birch extract (Be). After 6 days we tested the
supernatant's (Sn) chemotactic activity toward purified blood
eosinbnophils and T-lymphocyte proliferation. Dp induced a statistically
significant T-cell proliferation from atopics as compared to controls (p <
0.05), which correlated with the levels of eosinophil chemotactic activity
in the Sn (r = 0.713; p < 0.05). Measurable levels of IL-3, IL-5, and
GM-CSF were demonstrated in the Sn of Dp-stimulated PBMC from atopics,
while eosinophil locomotion toward different concentrations of recombinant
human (rh) IL-3, rhIL-5, and rhGM-CSF confirmed that these cytokines were
able to stimulate eosinophil chemotaxis in a close concentration range.
Preincubation of different concentrations of the same Sn with blocking
antisera demonstrated that anti-human (ah) IL-3, ahIL-5, and ahGM-CSF
effectively decreased eosinophil chemotaxis (p < 0.05; each comparison).
Thus PBMC activation with the relevant allergen induces the release by T
cells with a Th2 phenotype of chemotactic factors for eosinophils.
Ogawa M. Tsutsui T. Zou JP. Mu J. Wijesuriya R. Yu WG. Herrmann S.
Kubo T. Fujiwara H. Hamaoka T.
Enhanced induction of very late antigen 4/lymphocyte function-associated
_antigen 1-dependent T-cell migration to tumor sites following
_administration of interleukin 12.
Cancer Research. 57(11):2216-22, 1997 Jun 1.
Administration of interleukin 12 (IL-12) into mice bearing CSA1M, OV-HM,
Meth A, or MCH-1-A1 tumor induced complete regression of CSA1M and OV-HM
tumors but induced only a slight growth inhibition of Meth A and MCH-1-A1
tumors. These effects of IL-12 were associated with high and only marginal
levels of T-cell infiltration into CSA1M/OV-HM and Meth A/MCH-1-A1 tumor
masses, respectively. Here, we investigated the role of IL-12 in the
induction of T-cell migration. Spleen cells from untreated or
IL-12-treated CSA1M-bearing mice were stained in vitro with a fluorescein
chemical and transferred i.v. into IL-12-untreated CSA1M-bearing mice.
Migration of donor cells was quantitated by counting the number of
fluorescent cells on cryostat sections of tumor masses. Although only a
slight migration was detected for spleen cells from IL-12-untreated
CSA1M-bearing as well as IL-12-treated or untreated normal mice, enhanced
migration was observed for cells from IL-12-treated CSA1M-bearing mice. A
similar enhanced migration was observed for the OV-HM model. In contrast,
such an enhancement was only marginal in the Meth A and MCH-1-A1 models.
Immunohistochemical studies of tumors from IL-12-treated mice revealed
that the predominant T-cell subset was CD4+ in CSA1M and CD8+ in OV-HM
tumor masses. Consistent with this observation, the dominant subset of
migrating T cells was found to be CD4+ in the CSA1M and CD8+ in the OV-HM
models. T-cell migration was inhibited by pretreatment of recipients with
either combination of anti-very late antigen 4 + anti-vascular cell
adhesion molecule 1 or anti-lymphocyte function-associated antigen 1 +
anti-intercellular adhesion molecule 1 monoclonal antibody. These results
indicate that IL-12 can confer T cells with a capacity to migrate to tumor
sites through very late antigen 4/lymphocyte function-associated antigen 1
adhesion pathways and that the in vivo acquisition of such a capacity
following IL-12 treatment correlates with the induction of tumor
regression.
Marth T. Strober W. Seder RA. Kelsall BL.
Regulation of transforming growth factor-beta production by
interleukin-12.
Source
European Journal of Immunology. 27(5):1213-20, 1997 May.
The induction of peripheral tolerance following oral antigen
administration in several autoimmune disease and conventional animal
models correlates with the production of transforming growth factor-beta
(TGF-beta) and T helper type 2 (Th2) cytokines. The factors regulating
TGF-beta production and its relation to the Th2 response, however, have
not been defined. We demonstrate that the systemic administration of
antibodies to interleukin (IL)-12 to ovalbumin (OVA)-T cell receptor (TCR)
transgenic mice fed high doses of OVA, followed by systemic OVA challenge,
substantially enhances TGF-beta, but not IL-4 production by peripheral T
cells. Furthermore, we demonstrate in an in vitro T cell differentiation
model that naive (CD4+/Mel-14hi) OVA-TCR-T cells stimulated with
OVA-pulsed dendritic cells (DC) produce four- to fivefold higher amounts
of TGF-beta when cultured with anti-IL-12 or anti-interferon-gamma
(IFN-gamma). In this in vitro system, IL-4 was not required for TGF-beta
production by T cells; however, it appeared to enhance levels of TGF-beta
by promoting the growth of TGF-beta-producing cells. Our findings
demonstrate that IL-12 and IFN-gamma are important negative regulators of
TGF-beta production both in vivo and in vitro, and that their modulation
may be of benefit for the treatment of autoimmune disorders.
Stern AS. Magram J. Presky DH.
Institution
Hoffmann-La Roche Inc. Nutley, NJ 07110-1199, USA.
Title
Interleukin-12 an integral cytokine in the immune response. [Review] [147
refs]
Source
Life Sciences. 58(8):639-54, 1996.
Interleukin 12 (IL-12) is a heterodimeric cytokine that is produced
primarily by antigen-presenting cells and plays a primary role in the
induction of cell-mediated immunity. This function is promoted by the
IL-12 induced production of interferon-gamma (IFN-gamma) from both resting
and activated NK and T cells, by the proliferative activity of IL-12 on
activated NK and T cells, by enhancing the cytotoxic activity of NK cells,
and by supporting cytotoxic T lymphocyte generation. IL-12 and
IL-12-induced IFN-gamma promote the development of naive T cells into Th1
cells and the proliferation and IFN-gamma secretion by differentiated Th1
cells in response to antigen. IL-12 has been found to exhibit many of
these activities in vivo, as well as in vitro, and thus IL-12 plays an
important role in both innate resistance and antigen-specific adaptive
immunity to intracellular bacterial, fungal, and protozoan pathogens. Due
to its effects on T cells, recombinant IL-12 has been shown to have
therapeutic activity in a variety of mouse tumor and infectious disease
models and is being evaluated in clinical trials in human cancer patients.
IL-12 also appears to play a role in the genesis of some forms of
immunopathology, including endotoxin-induced shock and some autoimmune
diseases associated with aberrant Th1 activity. Therefore, IL-12
antagonists may also have therapeutic potential in the treatment of auto
immune disorders. [References: 147]
Li C. Goodrich JM. Yang X.
Interferon-gamma (IFN-gamma) regulates production of IL-10 and IL-12 in
human herpesvirus-6 (HHV-6)-infected monocyte/macrophage lineage.
Clinical & Experimental Immunology. 109(3):421-5, 1997 Sep.
To determine whether HHV-6 infection induces expression and production of
IL-10 and IL-12 in monocytes/macrophages, and to explore the influence of
IFN-gamma on cytokine production in HHV-6-infected cells, expression and
production of IL-10 and IL-12 were evaluated through reverse
transcription-polymerase chain reaction (RT-PCR) and sandwich ELISA. HHV-6
infection induced the expression and the production of IL-10 and IL-12 in
monocytes and THP-1 cells. Kinetic study showed that the expression of
IL-12 mRNA decreased with accumulation of IL-10 mRNA. Expression and
production of IL-12 were markedly increased when anti-human IL-10 MoAbs
were added to the cultures, implying that endogenous IL-10 induced by
HHV-6 inhibited IL-12 production. Addition of increasing concentrations of
IFN-gamma to the cultures of HHV-6-infected cells enhanced the expression
of IL-12 gene, while the accumulation of IL-10 mRNA was down-regulated.
Determination of protein levels of IL-10 and IL-12 by ELISA also showed
that IFN-gamma increased IL-12 and decreased IL-10 production. These
results suggest that IFN-gamma regulates the production of IL-10 and IL-12
at transcriptional level mainly through inhibiting endogenous IL-10
production in HHV-6-infected monocyte/macrophage lineage.
Mielcarek M. Graf L. Johnson G. Torok-Storb B.
Production of interleukin-10 by granulocyte colony-stimulating
factor-mobilized blood products: a mechanism for monocyte-mediated
suppression of T-cell proliferation.
Blood. 92(1):215-22, 1998 Jul 1.
Previous reports showed that granulocyte colony-stimulating factor
(G-CSF)-mobilized peripheral blood mononuclear cells (G-PBMC) are
hyporesponsive to alloantigen compared with control PBMC. In the current
study, _neutralizing antibodies to interleukin-10 (IL-10) . increased the
proliferative response of G-PBMC to alloantigen by 50. 14% (+/- 12.79%; n
= 8), whereas the proliferative response of control PBMC was not affected.
The inhibition of OKT3-stimulated CD4 cell proliferation by G-PBMC-derived
CD14(+) cells could also be abrogated by the addition of IL-10
neutralizing antibodies. Further, IL-10 levels correlated with the number
of CD14 cells in these cultures. Constitutive IL-10 mRNA levels detected
by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)
were 10-fold higher in G-PBMC compared with control PBMC. This translated
into significantly higher IL-10 levels after 24-hour lipopolysaccharide
(LPS) stimulation of G-PBMC compared with control PBMC (P = .036). IL-10
mRNA levels were also fivefold higher in isolated G-PBMC-derived CD14
cells compared with control CD14 cells. This corresponded to increased
constitutive production of IL-10 by isolated G-PBMC-derived CD14 cells
compared with control CD14 cells (357.2 +/- 104.5 v 51.7 +/- 30.5, P =
.051). In conclusion, these data suggest that monocytes contained within
G-PBMC, which, in comparison to marrow, are increased in absolute number
and relative proportion to T cells, may suppress T-cell responsiveness by
secretion of IL-10.
Rohde T. MacLean DA. Richter EA. Kiens B. Pedersen BK.
Prolonged submaximal eccentric exercise is associated with increased
levels of plasma IL-6.
American Journal of Physiology. 273(1 Pt 1):E85-91, 1997 Jul.
To study the relationship between exercise-related muscle proteolysis and
the cytokine response, a prolonged eccentric exercise model of one leg was
used. Subjects performed two trials [a branched-chain amino acid (BCAA)
supplementation and a control trial]. The release of amino acids from
muscle during and after the eccentric exercise was decreased in the BCAA
trial, suggesting a suppression of net muscle protein degradation. The
plasma concentrations of interleukin (IL)-6 increased from 0.75 +/- 0.19
(preexercise) to 5.02 +/- 0.96 pg/ml (2 h postexercise) in the control
trial and in the BCAA supplementation trial from 1.07 +/- 0.41 to 4.15 +/-
1.21 pg/ml. Eccentric exercise had no effect on the concentrations of
neutrophils, lymphocytes, CD16+/CD56+, CD4+, CD8+, CD14+/CD38+, lymphocyte
proliferative response, or cytotoxic activities. BCAA supplementation
reduced the concentration of CD14+/CD38+ cells. This study shows that the
concentration of IL-6 in plasma is increased after prolonged eccentric
exercise and suggests that the cytokine response is independent of the
muscle proteolysis that occur during exercise.
Venkatraman JT. Pendergast D.
Effects of the level of dietary fat intake and endurance exercise on
plasma cytokines in runners.
Medicine & Science in Sports & Exercise. 30(8):1198-204, 1998 Aug.
PURPOSE:Chronic exercise and high fat diets have been associated with
immune suppression. We have reported the effects of level of dietary fat
and exercise on lymphocyte subsets, proliferative response, and in vitro
production of cytokines by peripheral blood mononuclear cells of runners.
The present study was planned to further investigate whether the
mechanisms of action of dietary fats is through their modulation of plasma
cytokines in runners. METHODS: This study compared plasma cytokines at
rest and after endurance exercise at 80% of V02max in female (N = 8-10)
and male (N = 8-10) runners after eating diets comprised of 17% (LF), 32%
(MF), and 41% (HF) fats (4 wk each). RESULTS: The level of interleukin-1
beta (IL-1 beta) was independent of gender, exercise, and level of dietary
fat. tumor necrosis factor (TNF-alpha) level was higher in the plasma of
men compared with that in women runners, and the level of these two
cytokines increased with increasing level of dietary fat. Plasma
interleukin-2 (IL-2) level (a cytokine involved in enhancing T cell
functions for host defense) was significantly higher in men compared with
that in women runners and decreased in men with increase dietary fat.
Plasma interleukin-6(IL-6) level was significantly lower after the
endurance run, and IL-6 levels decreased with increase in dietary fat.
CONCLUSIONS: Data from the present study suggest that dietary fat has
differential effects on plasma cytokine levels in runners. Increasing the
level of dietary fat significantly increased endurance run time and had no
adverse effects on the level of plasma IL-2 and pro-inflammatory cytokines
(IL-1 beta, IL-6 and TNF-alpha in runners.
ÝÏÎ-? . 2ÈÍÒÅÐËÅÉÊÈÍÛ 0 (ÈË) ÐÅÃÓËßÖÈß ÈÍÒÅÐËÅÉÊÈÍÀÌÈ ÈË-1 - ïðîâîñïàëèòåëüûíé àãåíò, ïèðîãåí, èììóíîïîýòèí, íåéðî- ìåäèàòîð ÈË-2 - ìèòîãåí Ò-ëèìôîöèòîâ, ñòèìóëÿòîð ÅÊÊ (êèëëåðî
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